(R)-4-[(3S,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Dihydroxy-3-(5-hydroxy-pentyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid tert-butyl ester | 147589-54-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (R)-4-[(3S,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Dihydroxy-3-(5-hydroxy-pentyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid tert-butyl ester
• CAS: 147589-54-6
• 化学式: C₃₃H₅₈O₆
• 分子量: 550.82
• InChiKey: OCEIJFRVAXRDRZ-GPHNGDAYSA-N

物化性质

• 沸点：
  634.7±55.0 °C(predicted)
• 密度：
  1.10±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  (R)-4-[(3S,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Dihydroxy-3-(5-hydroxy-pentyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid tert-butyl ester 在 palladium on activated charcoal 吡啶 、 sodium azide 、 氢气 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 (R)-4-[(3S,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3-(5-Amino-pentyloxy)-7,12-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid tert-butyl ester
  参考文献：
  名称：

  Preparation of 3α- and 3β-(ω-aminoalkoxy)-7α,12α-dihydroxy-5β-cholanoic acid esters: Versatile shuttles for drug targeting

  摘要：

  Simple methodology for the preparation of 3alpha- and 3beta-(omega-aminoalkoxy)-cholanoic acid esters 7, 9 11, 13 and 15 is described starting from readily available bile acid derivatives. Protecting groups are not required

  DOI：

  10.1016/0040-4039(93)89020-q
• 作为产物：
  描述：

  (R)-4-[(3S,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Dihydroxy-3-(5-hydroxy-pentyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid 在 高氯酸 吡啶 、 sodium hydroxide 、 氯化亚砜 作用下， 以 甲苯 为溶剂， 生成 (R)-4-[(3S,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Dihydroxy-3-(5-hydroxy-pentyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid tert-butyl ester
  参考文献：
  名称：

  Preparation of 3α- and 3β-(ω-aminoalkoxy)-7α,12α-dihydroxy-5β-cholanoic acid esters: Versatile shuttles for drug targeting

  摘要：

  Simple methodology for the preparation of 3alpha- and 3beta-(omega-aminoalkoxy)-cholanoic acid esters 7, 9 11, 13 and 15 is described starting from readily available bile acid derivatives. Protecting groups are not required

  DOI：

  10.1016/0040-4039(93)89020-q