(+/-)trans-2,5-bis(3,4,5-Trimethoxyphenyl)-1,3-dioxolane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (+/-)trans-2,5-bis(3,4,5-Trimethoxyphenyl)-1,3-dioxolane
• 英文别名: (2S,4S)-2,4-bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane
• 化学式: C₂₁H₂₆O₈
• 分子量: 406.4
• InChiKey: DUAYHYGJMLZLCE-NQIIRXRSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  73.8
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Method for controlling the plasma level of lipoproteins
  申请人：NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO

  公开号：EP0875247A1

  公开（公告）日：1998-11-04

  A compound which is an antagonist of platelet activating factor (PAF-antagonist) or a structurally related compound thereof not having PAF-antagonistic activity can be used for decreasing the plasma level of lipoprotein(a) and/or increasing the plasma level of high-density lipoprotein. The compound may be an azepine derivative, especially a benzo- or thienotriazolo-diazepine derivative, a diphenyl-tetrahydrofuran or diphenyldioxolane derivative or a tetrahydrofuran phospholipid analogue.

  血小板活化因子拮抗剂（PAF-antagonist）化合物或其结构相关的不具有 PAF 拮抗活性的化合物可用于降低血浆中脂蛋白（a）的水平和/或提高血浆中高密度脂蛋白的水平。该化合物可以是氮杂卓衍生物，特别是苯并三唑或噻吩三唑-二氮杂卓衍生物、二苯基四氢呋喃或二苯基二氧戊环衍生物或四氢呋喃磷脂类似物。
• Platelet-activated factor antagonists as analgesic, anti-inflammatory, uterine contraction inhibiting, and anti-tumor agents
  申请人：——

  公开号：US20040028756A1

  公开（公告）日：2004-02-12

  Antagonists to platelet-activating factor provide analgesic effects as well as limit the release of inflammatory mediators. Use of these antagonists in the form of pharmaceutical compositions or nutritionals is beneficial (1) in the treatment of acute and/or chronic pain; (2) in the inhibition of inappropriate or excessive contraction of the uterus; (3) in the treatment of septic shock; and (4) in the inhibition of angiogenesis and/or tumor cell proliferation.

  血小板活化因子拮抗剂具有镇痛效果，并能限制炎症介质的释放。以药物组合物或营养品的形式使用这些拮抗剂有利于：(1) 治疗急性和/或慢性疼痛；(2) 抑制子宫不适当或过度收缩；(3) 治疗脓毒性休克；以及 (4) 抑制血管生成和/或肿瘤细胞增殖。
• Platelet-activating factor antagonists as analgesic, anti-inflammatory, uterine contraction inhibiting, and anti-tumor agents
  申请人：Wurtman J. Richard

  公开号：US20050032713A1

  公开（公告）日：2005-02-10

  Antagonists to platelet-activating factor provide analgesic effects as well as limit the release of inflammatory mediators. Use of these antagonists in the form of pharmaceutical compositions or nutritionals is beneficial (1) in the treatment of acute and/or chronic pain; (2) in the inhibition of inappropriate or excessive contraction of the uterus; (3) in the treatment of septic shock; and (4) in the inhibition of angiogenesis and/or tumor cell proliferation.

  血小板活化因子拮抗剂具有镇痛效果，并能限制炎症介质的释放。以药物组合物或营养品的形式使用这些拮抗剂有利于：(1) 治疗急性和/或慢性疼痛；(2) 抑制子宫不适当或过度收缩；(3) 治疗脓毒性休克；以及 (4) 抑制血管生成和/或肿瘤细胞增殖。
• US5631246A
  申请人：——

  公开号：US5631246A

  公开（公告）日：1997-05-20
• US6444664B1
  申请人：——

  公开号：US6444664B1

  公开（公告）日：2002-09-03