diethyl 2-(3-methyl-2-oxobutyl)-2-(prop-2-ynyl)malonate | 1159014-19-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: diethyl 2-(3-methyl-2-oxobutyl)-2-(prop-2-ynyl)malonate
• CAS: 1159014-19-3
• 化学式: C₁₅H₂₂O₅
• 分子量: 282.337
• InChiKey: BFPLZHLLTGGYHY-UHFFFAOYSA-N

物化性质

• 沸点：
  369.3±42.0 °C(predicted)
• 密度：
  1.067±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  Diethyl 2-[(3,3-dimethyloxiran-2-yl)methyl]-2-prop-2-ynylpropanedioate 在 tin(IV) triflimidate 作用下， 以 硝基甲烷 为溶剂， 反应 6.0h， 以70%的产率得到Ethyl 5-(2-hydroxypropan-2-yl)-2-oxo-3-prop-2-ynyloxolane-3-carboxylate
  参考文献：
  名称：

  Tin(IV) triflimidate-catalyzed cyclization of epoxy esters to functionalized δ-hydroxy-γ-lactones

  摘要：

  In the presence of 5 mol % of tin(IV) triflimidate, a cyclization reaction of epoxyesters to delta-hydroxy-gamma-lactones proceeding in 46-98% yields without additives, ligands, or co-catalysts was observed. The cyclization to five-membered rings is greatly favored compared to the possible six-membered rings formation and is probably under the control of a Thorpe-Ingold type effect. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.055