4,6-二氨基异邻苯二甲酸 | 13324-94-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4,6-二氨基异邻苯二甲酸
• 英文名称: 4,6-diamino-isophthalic acid
• 英文别名: 4,6-Diamino-isophthalsaeure；4,6-Diaminobenzene-1,3-dicarboxylic acid
• CAS: 13324-94-2
• 化学式: C₈H₈N₂O₄
• mdl: MFCD00580490
• 分子量: 196.163
• InChiKey: ILPDVOFDSNNCNY-UHFFFAOYSA-N

物化性质

• 沸点：
  503.7±50.0 °C(Predicted)
• 密度：
  1.647±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  127
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• 海关编码：
  2922499990

反应信息

• 作为反应物：
  描述：

  4,6-二氨基异邻苯二甲酸 、 乙酸酐 生成 2,8-dimethyl-benzo[1,2-d;5,4-d']bis[1,3]oxazine-4,6-dione
  参考文献：
  名称：

  Bogert; Kropff, Journal of the American Chemical Society, 1909, vol. 31, p. 847

  摘要：

  DOI：
• 作为产物：
  描述：

  N,N'-(4,6-dimethyl-m-phenylene)-bis-acetamide 在 potassium permanganate 作用下， 生成 4,6-二氨基异邻苯二甲酸
  参考文献：
  名称：

  Bogert; Kropff, Journal of the American Chemical Society, 1909, vol. 31, p. 847

  摘要：

  DOI：

文献信息

• Novel antiallergic and antiinflammatory agents. Part II: Synthesis and pharmacology of TYB-2285 and its related compounds
  作者：Masakazu Ban、Hiroaki Taguchi、Takeo Katsushima、Mitsuru Takahashi、Kiyotaka Shinoda、Akihiko Watanabe、Takanari Tominaga

  DOI：10.1016/s0968-0896(98)00066-2

  日期：1998.7

  chloride derivatives in pyridine. Hydrolysis of acetyl compounds gave hydroxy derivatives, from which other acyl derivatives could be synthesized. These compounds were tested in the rat PCA (passive cutaneous anaphylaxis) assay by oral administration. Benzonitrile derivatives (4c, 5c, 6c, 4h, 5h) exhibited notable inhibition in this assay. Compounds 5c and 6c also showed remarkable inhibition of eosinophil

  通过在吡啶中用乙醇酰氯衍生物处理相应的间二氨基苯衍生物，合成了一系列间二（糖基氨基）苯衍生物。乙酰基化合物的水解产生羟基衍生物，从中可以合成其他酰基衍生物。这些化合物在口服PCA（被动性皮肤过敏反应）试验中进行了测试。苯甲腈衍生物（4c，5c，6c，4h，5h）在该试验中表现出显着的抑制作用。化合物5c和6c在10（-8）-10（-5）M的范围内也显示出嗜酸性粒细胞对TNF-（肿瘤坏死因子）α处理的HUVEC（人脐静脉内皮细胞）粘附的显着抑制。化合物5c是目前正在日本进行TYB-2285（图1）研究，用于II期临床研究中的哮喘和特应性皮炎。
• RESIN COMPOSITION AND SEMICONDUCTOR DEVICE BOARD
  申请人：Osaku Yumi

  公开号：US20140087136A1

  公开（公告）日：2014-03-27

  A resin composition which contains a binder resin (A), radiation-sensitive compound (B), silane-modified resin (C), and antioxidant (D), wherein a content of the silane-modified resin (C) is 0.1 to 150 parts by weight with respect to 100 parts by weight of the binder resin (A), a content of the antioxidant (D) is 0.1 to 10 parts by weight with respect to 100 parts by weight of the binder resin (A), and an amount of warping is 14 μm or less when using the resin composition to form a thickness 2 to 3 μm resin film and baking the formed resin film at 230° C. is provided.

  一种树脂组合物，包含粘合剂树脂（A），辐射敏感化合物（B），硅改性树脂（C）和抗氧化剂（D），其中硅改性树脂（C）的含量相对于100份粘合剂树脂（A）为0.1至150份重量，抗氧化剂（D）的含量相对于100份粘合剂树脂（A）为0.1至10份重量，并且使用该树脂组合物形成2至3μm厚度的树脂膜并在230°C下烘烤形成的树脂膜翘曲量为14μm或以下。
• Beyond iron: metal-binding activity of the <i>Pseudomonas</i> quinolone signal-motif
  作者：Dávid Szamosvári、Viktoriia Savchenko、Natalie Badouin、Thomas Böttcher

  DOI：10.1039/d3ob00710c

  日期：——

  PQS-motif has proven as privileged structure with great potential which is why we here explored the synthesis of two different types of crosslinked dimeric PQS-motifs as potential iron chelators. These compounds indeed chelated ferric iron and produced colorful and fluorescent complexes also with other metal ions. Inspired by these results, we revisited the metal ion binding capabilities of the natural product

  假单胞菌喹诺酮信号（PQS）是控制人类病原体铜绿假单胞菌毒力的重要群体感应信号。PQS 还表现出P的多种附加生物学功能。铜绿假单胞菌，包括捕获三价铁。PQS 基序已被证明是具有巨大潜力的特殊结构，这就是为什么我们在这里探索合成两种不同类型的交联二聚体 PQS 基序作为潜在的铁螯合剂。这些化合物确实与三价铁螯合，并与其他金属离子产生彩色荧光络合物。受这些结果的启发，我们重新审视了天然产物 PQS 的金属离子结合能力，并能够检测到三价铁以外的更多金属络合物，并通过质谱法确认络合物的化学计量。
• Positive photosensitive polyimide resin composition
  申请人：NISSAN CHEMICAL INDUSTRIES LTD.

  公开号：EP0424940A2

  公开（公告）日：1991-05-02

  A positive photosensitive polyimide resin composition which comprises 100 parts by weight of an organic solvent-soluble polyimide resin and 1-100 parts by weight of an ο-quinonediazide compound, said polyimide resin being composed of the repeating units represented by formulas [I] and [II] below (where R₁ is a divalent organic group to constitute a diamine which has one or more groups of at least one kind selected from the group consisting of phenolic hydroxyl group, carboxyl group, thiophenol group, and sulfonic group; R₃ is a divalent organic group having no phenolic hydroxyl group, carboxyl group, thiophenol group, and sulfonic group; and R₂ and R₄ each are a tetravalent organic group constituting a tetracarboxylic acid and a derivative thereof when R₁ has one or more groups of at least one kind selected from the group consisting of carboxyl group and sulfonic group and has no phenolic hydroxyl group and thiophenol group, or R₂ and R₄ each are a tetravalent organic group constituting a tetracarboxylic acid and a derivative thereof composed of four carbonyl groups which are not attached directly to the aromatic ring when R₁ has a phenolic hydroxyl group and/or thiophenol group) with the molar percentage (a) of the repeating units represented by formula [I] being in the range of 1 mol% ≦ a ≦ 90 mol% and the molar percentage (b) of the repeating units represented by formula [II] being in the range of 10 mol% ≦ b ≦ 99 mol%, and having a reduced viscosity of 0.05-3.0 dℓ/g (measured at a concentration of 0.5 g/ℓ in N-methylpyrrolidone at 30°C).

  一种正性光敏聚酰亚胺树脂组合物，它由重量份数为 100 份的有机溶剂溶性聚酰亚胺树脂和重量份数为 1-100 份的ο-醌噻嗪化合物组成，所述聚酰亚胺树脂由以下式[I]和[II]所代表的重复单元组成 (其中，R₁ 是二价有机基团，以构成二元胺，该二元胺具有一个或多个至少选自酚羟基、羧基、噻吩酚基和磺酸基的基团；R₃ 是不含酚羟基、羧基、噻吩酚基和磺酸基的二价有机基团；和 R₂ 和 R₄ 分别是构成四羧酸及其衍生物的四价有机基团，当 R₁ 具有至少一种选自羧基和磺酰基的一个或多个基团，且不具有酚羟基和噻吩酚基时、或 R₂ 和 R₄ 各为构成四羧酸的四价有机基团及其衍生物，当 R₁ 具有酚羟基和/或噻吩酚基时，由四个不直接连接到芳香环上的羰基组成。） 由式[I]代表的重复单元的摩尔百分比（a）在 1 mol% ≦ a ≦ 90 mol% 的范围内，由式[II]代表的重复单元的摩尔百分比（b）在 10 mol% ≦ b ≦ 99 mol% 的范围内，且具有 0.05-3.0dℓ/g（在N-甲基吡咯烷酮中浓度为0.5g/ℓ，温度为30℃时测量）。
• Polymer scale preventive agent, polymerization vessel effective in preventing polymer scale deposition, and process of producing polymer using said vessel
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：EP0540934A1

  公开（公告）日：1993-05-12

  A polymer scale preventive agent for use in polymerization of a monomer having an ethylenically unsaturated double bond, comprising an alkaline solution containing a condensation product of (A) an aromatic amine compound and (B) a quinone compound. This agent is used for forming a coating on the inner wall, etc. of a polymerization vessel. Such a vessel is effective in preventing polymer scale deposition and useful in producing a polymer that shows very few fish eyes and good whiteness when formed into sheets or the like.

  一种聚合物防垢剂，用于具有乙烯不饱和双键的单体的聚合，由碱性溶液组成，其中含有 (A) 芳香胺化合物和 (B) 醌化合物的缩合产物。该剂用于在聚合容器的内壁等处形成涂层。这种容器可有效防止聚合物鳞片沉积，并有助于生产出在形成片材或类似材料时很少显示鱼眼和良好白度的聚合物。