N2-[N-acetyl-3-(1-naphthyl)-D-alanyl]-L-arginyl-3-(1-naphthyl)-L-alaninamide | 475498-00-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N2-[N-acetyl-3-(1-naphthyl)-D-alanyl]-L-arginyl-3-(1-naphthyl)-L-alaninamide
• 英文别名: Ac-D-1Nal-Arg-1Nal-NH2；(2S)-2-[[(2R)-2-acetamido-3-naphthalen-1-ylpropanoyl]amino]-N-[(2S)-1-amino-3-naphthalen-1-yl-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide
• CAS: 475498-00-1
• 化学式: C₃₄H₃₉N₇O₄
• 分子量: 609.728
• InChiKey: YSWHSOZNEZJUNE-OIFRRMEBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  45
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  195
• 氢给体数：
  6
• 氢受体数：
  5

文献信息

• ARGININE DERIVATIVES
  申请人：TAISHO PHARMACEUTICAL CO., LTD

  公开号：EP1388537A1

  公开（公告）日：2004-02-11

  An arginine derivative represented by the formula: [wherein Ar1 and Ar2 may be the same or different, and are each a phenyl group, a substituted phenyl group, a naphthyl group, a substituted naphthyl group or a heteroaromatic ring group containing one or more of nitrogen, oxygen and sulfur atoms; Y1 is a C1-5 alkylene group, a C2-5 alkenylene group or a single bond; and the C1-5 alkylene group optionally contains a carbon atom substituted with a phenyl group, a substituted phenyl group, a naphthyl group, a substituted naphthyl group or a C1-10 acylamino group; Q is a carbonyl group or a sulfonyl group; Y2 is a C1-5 alkylene group; the C1-5 alkylene group optionally contains a carbon atom substituted with a phenyl group, a substituted phenyl group, a naphthyl group, a substituted naphthyl group, a hydroxyl group, a carbamoyl group, a mono-C1-5 alkylamide group or a di-C1-5 alkylamide group], or a pharmaceutically acceptable salt thereof. There are provided peptidergic ligands which have the affinity and specificity to MC4 receptor.

  一种以以下式表示的精氨酸衍生物：[其中Ar1和Ar2可以相同或不同，分别为苯基，取代苯基，萘基，取代萘基或含有一个或多个氮，氧和硫原子的杂环芳基环；Y1为C1-5烷基，C2-5烯基烷基或单键；C1-5烷基可以选用含有苯基，取代苯基，萘基，取代萘基或C1-10酰胺基的碳原子进行取代；Q为羰基或磺酰基；Y2为C1-5烷基；C1-5烷基可以选用含有苯基，取代苯基，萘基，取代萘基，羟基，氨基甲酰基，单C1-5烷基酰胺基或双C1-5烷基酰胺基的碳原子进行取代]，或其药学上可接受的盐。提供了具有MC4受体亲和力和特异性的肽类配体。
• Arginine derivatives
  申请人：——

  公开号：US20040147567A1

  公开（公告）日：2004-07-29

  An arginine derivative represented by the formula: 1 [wherein Ar 1 and Ar 2 may be the same or different, and are each a phenyl group, a substituted phenyl group, a naphthyl group, a substituted naphthyl group or a heteroaromatic ring group containing one or more of nitrogen, oxygen and sulfur atoms; Y 1 is a C 1-5 alkylene group, a C 2-5 alkenylene group or a single bond; and the C 1-5 alkylene group optionally contains a carbon atom substituted with a phenyl group, a substituted phenyl group, a naphthyl group, a substituted naphthyl group or a C 1-10 acylamino group; Q is a carbonyl group or a sulfonyl group; Y 2 is a C 1-5 alkylene group; the C 1-5 alkylene group optionally contains a carbon atom substituted with a phenyl group, a substituted phenyl group, a naphthyl group, a substituted naphthyl group, a hydroxyl group, a carbamoyl group, a mono-C 1-5 alkylamide group or a di-C 1-5 alkylamide group], or a pharmaceutically acceptable salt thereof. There are provided peptidergic ligands which have the affinity and specificity to MC 4 receptor.

  一种精氨酸衍生物，其分子式为 1 其中 Ar 1 和 Ar 2 可以相同或不同，且各自为苯基、取代苯基、萘基、取代萘基或含有一个或多个氮、氧和硫原子的杂芳环基团；Y 1 是一个 C 1-5 烯基、C 2-5 烯基或单键；而 C 1-5 烯基可选择包含一个被苯基、取代苯基、萘基、取代萘基或 C 1-10 酰氨基； Q 是羰基或磺酰基； Y 2 是一个 C 1-5 烯基；C 1-5 烯基可选择包含一个被苯基、取代苯基、萘基、取代萘基、羟基、氨基甲酰基、单-C 1-5 烷基酰胺基团或二-C 1-5 烷基酰胺基团或二-C 1-5 烷基酰胺基团或其药学上可接受的盐。 提供的肽配体对 MC 4 受体的亲和性和特异性。