N~2~-(2-Aminoethyl)-L-glutamine | 45102-55-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N~2~-(2-Aminoethyl)-L-glutamine
• 英文别名: (2S)-5-amino-2-(2-aminoethylamino)-5-oxopentanoic acid
• CAS: 45102-55-4
• 化学式: C₇H₁₅N₃O₃
• 分子量: 189.21
• InChiKey: BRHPGXCLGBMXKW-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.6
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Nanoparticles with protected interiors, and methods of use thereof
  申请人：Universidade de Santiago de Compostela

  公开号：US10471020B2

  公开（公告）日：2019-11-12

  The present invention generally relates to particles, including nanoparticles, for example, for drug delivery or other applications. Certain aspects of the present invention are generally directed to particles, such as nanoparticles, comprising an inner portion and a coating. The inner portion may contain insulin or other therapeutic molecules for delivery to a living organism. In some cases, the molecules may be electrostatically complexed with an oppositely-charged peptide, such as an oligoarginine, or other species. The therapeutic molecules may also be water soluble. In some cases, the peptide may be conjugated to a hydrophobic portion, such as cholesterol, lauric acid, or a fatty acid chain. This hydrophobic modification may facilitate complex formation with the therapeutic molecule and the stability of the resulting complex. The complex typically is surrounded by a coating, which may protect the complex. For example, the coating may include polymers such as poly(glutamic acid) and poly(ethylene glycol). In some cases, the coated complex may also facilitate transport across cells, e.g., within the gastrointestinal tract. Other aspects of the invention are generally directed to methods of making or using such compositions, kits including such compositions, or the like.

  本发明一般涉及颗粒，包括纳米颗粒，例如，用于药物输送或其他应用。本发明的某些方面通常针对颗粒，如纳米颗粒，包括内部部分和涂层。内部部分可包含胰岛素或其他治疗分子，用于向活生物体递送。在某些情况下，这些分子可与带相反电荷的肽，如低聚精氨酸，或其他物质进行静电络合。治疗分子也可以是水溶性的。在某些情况下，肽可与疏水部分（如胆固醇、月桂酸或脂肪酸链）共轭。这种疏水修饰可促进与治疗分子形成复合物，并提高复合物的稳定性。复合物周围通常有一层可保护复合物的涂层。例如，涂层可包括聚（谷氨酸）和聚（乙二醇）等聚合物。在某些情况下，涂层复合物还可促进细胞间的转运，例如在胃肠道内的转运。本发明的其它方面一般涉及制造或使用此类组合物的方法、包括此类组合物的试剂盒或类似物。
• NANOCAPSULES WITH A POLYMER SHELL
  申请人：Universidade De Santiago De Compostela

  公开号：EP2664324B1

  公开（公告）日：2019-09-25
• DRUG DELIVERY SYSTEMS AND METHODS COMPRISING POLYSIALIC ACID AND/OR OTHER POLYMERS
  申请人：Universidade de Santiago de Compostela

  公开号：EP3703666A1

  公开（公告）日：2020-09-09
• NANOPARTICLES WITH PROTECTED INTERIORS, AND METHODS OF USE THEREOF
  申请人：Universidade de Santiago de Compostela

  公开号：US20180078510A1

  公开（公告）日：2018-03-22

  The present invention generally relates to particles, including nanoparticles, for example, for drug delivery or other applications. Certain aspects of the present invention are generally directed to particles, such as nanoparticles, comprising an inner portion and a coating. The inner portion may contain insulin or other therapeutic molecules for delivery to a living organism. In some cases, the molecules may be electrostatically complexed with an oppositely-charged peptide, such as an oligoarginine, or other species. The therapeutic molecules may also be water soluble. In some cases, the peptide may be conjugated to a hydrophobic portion, such as cholesterol, lauric acid, or a fatty acid chain. This hydrophobic modification may facilitate complex formation with the therapeutic molecule and the stability of the resulting complex. The complex typically is surrounded by a coating, which may protect the complex. For example, the coating may include polymers such as poly(glutamic acid) and poly(ethylene glycol). In some cases, the coated complex may also facilitate transport across cells, e.g., within the gastrointestinal tract. Other aspects of the invention are generally directed to methods of making or using such compositions, kits including such compositions, or the like.
• US9415019B2
  申请人：——

  公开号：US9415019B2

  公开（公告）日：2016-08-16