[3-(Anthracen-9-ylmethoxy)-5-hydroxymethyl-phenoxy]-acetic acid tert-butyl ester | 910874-99-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: [3-(Anthracen-9-ylmethoxy)-5-hydroxymethyl-phenoxy]-acetic acid tert-butyl ester
• CAS: 910874-99-6
• 化学式: C₂₈H₂₈O₅
• 分子量: 444.527
• InChiKey: UYUGLEGVSHMJCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.78
• 重原子数：
  33.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  64.99
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  [3-(Anthracen-9-ylmethoxy)-5-hydroxymethyl-phenoxy]-acetic acid tert-butyl ester 在 pyridium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以85%的产率得到[3-(Anthracen-9-ylmethoxy)-5-formyl-phenoxy]-acetic acid tert-butyl ester
  参考文献：
  名称：

  Selective Sensing of Metalloproteins from Nonselective Binding Using a Fluorogenic Amphiphilic Polymer

  摘要：

  Nonconjugated fluorogenic amphiphilic polymers containing an anthracene chromophore exhibit fluorescence quenching in the presence of metalloproteins, although the binding of the polymer to proteins is not selective. The reason for this difference is that the possible conformational changes that protein binding could bring about on a polymer do not affect the fluorescence properties of a pendent chromophore in nonconjugated polymers. This is in contrast to the nonspecific binding and response found with conjugated polymers to proteins.

  DOI：

  10.1021/ja063544v
• 作为产物：
  描述：

  溴乙酸叔丁酯 在 18-冠醚-6 、 potassium carbonate 、 sodium iodide 作用下， 以 丙酮 为溶剂， 反应 54.0h， 生成 [3-(Anthracen-9-ylmethoxy)-5-hydroxymethyl-phenoxy]-acetic acid tert-butyl ester
  参考文献：
  名称：

  Selective Sensing of Metalloproteins from Nonselective Binding Using a Fluorogenic Amphiphilic Polymer

  摘要：

  Nonconjugated fluorogenic amphiphilic polymers containing an anthracene chromophore exhibit fluorescence quenching in the presence of metalloproteins, although the binding of the polymer to proteins is not selective. The reason for this difference is that the possible conformational changes that protein binding could bring about on a polymer do not affect the fluorescence properties of a pendent chromophore in nonconjugated polymers. This is in contrast to the nonspecific binding and response found with conjugated polymers to proteins.

  DOI：

  10.1021/ja063544v