2-Acetyl-6-aminohexanoic acid | 91856-37-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 2-Acetyl-6-aminohexanoic acid
• CAS: 91856-37-0
• 化学式: C₈H₁₅NO₃
• 分子量: 173.21
• InChiKey: BHRARTUEBYQRLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID
  申请人：Burk Mark J.

  公开号：US20120282661A1

  公开（公告）日：2012-11-08

  The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.

  本发明提供了一种非自然存在的微生物有6-氨基己酸、己内酰胺、六亚甲基二胺或丙酮酸途径。该微生物含有至少一种外源核酸，编码相应的6-氨基己酸、己内酰胺、六亚甲基二胺或丙酮酸途径中的酶。本发明还提供了一种生产6-氨基己酸、己内酰胺、六亚甲基二胺或丙酮酸的方法。该方法可以包括培养6-氨基己酸、己内酰胺或六亚甲基二胺产生微生物，其中微生物在适当的条件下表达至少一种外源核酸编码的6-氨基己酸、己内酰胺、六亚甲基二胺或丙酮酸途径酶，以产生相应的产物，持续一定的时间。
• MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF HEXAMETHYLENEDIAMINE
  申请人：Genomatica, Inc.

  公开号：EP3611254A1

  公开（公告）日：2020-02-19

  The invention provides a non-naturally occurring microbial organism having a hexamethylenediamine pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the hexamethylenediamine pathway. The invention additionally provides a method for producing hexamethylenediamine. The method can include culturing a hexamethylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a hexamethylenediamine pathway enzyme in a sufficient amount to produce the hexamethylenediamine, under conditions and for a sufficient period of time to produce hexamethylenediamine.

  本发明提供了一种具有六亚甲基二胺途径的非天然微生物。该微生物含有至少一种编码六亚甲基二胺途径中酶的外源核酸。本发明还提供了一种生产六亚甲基二胺的方法。该方法可包括培养产生六亚甲基二胺的微生物有机体，其中微生物有机体表达至少一种编码六亚甲基二胺途径酶的外源核酸，其数量足以产生六亚甲基二胺，其条件和时间足以产生六亚甲基二胺。
• Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
  申请人：Genomatica, Inc.

  公开号：US10150977B2

  公开（公告）日：2018-12-11

  The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.

  本发明提供了一种具有 6-氨基己酸、己内酰胺、六偏二胺或左旋维酸途径的非天然微生物。该微生物有机体含有至少一种外源核酸，该核酸编码相应 6-氨基己酸、己内酰胺、六偏二胺或左旋维酸途径中的酶。本发明还提供了一种生产 6-氨基己酸、己内酰胺、己二胺或乙酰丙酸的方法。该方法可包括培养生产 6-氨基己酸、己内酰胺或六甲撑二胺的微生物有机体，其中微生物有机体表达至少一种编码 6-氨基己酸、己内酰胺或六甲撑二胺的外源核酸、在生产 6-氨基己酸、己内酰胺、己二胺或乙酰丙酸的条件下，表达至少一种编码 6-氨基己酸、己内酰胺、己二胺或乙酰丙酸途径酶的外源核酸，且该酶的量足以生产相应的产品，并能持续足够长的时间。
• Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam related thereto
  申请人：Genomatica, Inc.

  公开号：US10150976B2

  公开（公告）日：2018-12-11

  Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.

  本文提供了一种非天然存在的微生物有机体，它具有甲醇代谢途径，可以在甲醇存在的情况下提高还原当量的可用性。这种还原当量可用于提高微生物有机体生产的有机化合物的产品产量，如己二酸盐、6-氨基己酸盐、六甲基二胺或己内酰胺。本文还提供了使用此类微生物生产己二酸酯、6-氨基己酸酯、己二胺或己内酰胺的方法。
• Method of producing and processing diamines from an engineered microorganism
  申请人：Genomatica, Inc.

  公开号：US10711289B2

  公开（公告）日：2020-07-14

  Provided is a method of producing and isolating a diamine produced by microbial fermentation that minimizes undesirable salt formation to provide a lower cost process.

  本发明提供了一种生产和分离微生物发酵法生产的二胺的方法，该方法可最大限度地减少不希望形成的盐，从而提供一种成本更低的工艺。