2-(6,7-dihydrobenzo[b]thiophen-4(5H)-ylidene)acetic acid | 102154-32-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-(6,7-dihydrobenzo[b]thiophen-4(5H)-ylidene)acetic acid
• 英文别名: 4-Carboxymethylidene-4,5,6,7-tetrahydrobenzo[b]thiophene；2-(6,7-dihydro-5H-1-benzothiophen-4-ylidene)acetic acid
• CAS: 102154-32-5
• 化学式: C₁₀H₁₀O₂S
• 分子量: 194.254
• InChiKey: AXQOKFDELGKCPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(6,7-dihydrobenzo[b]thiophen-4(5H)-ylidene)acetic acid 在 N,N-二甲基甲酰胺 氯化亚砜 作用下， 反应 0.08h， 生成
  参考文献：
  名称：

  4,5,6,7-Tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands

  摘要：

  本发明涉及对sigma (σ)受体具有药理活性的化合物，更具体地涉及一些4,5,6,7-四氢苯并[b]噻吩衍生物，其中n选择为0、1、2、3或4；m选择为0、1或2；虚线---代表单键或双键；本发明还涉及制备这种化合物的方法、包含它们的制药组合物以及它们在治疗和预防中的应用，特别是用于治疗精神病。

  公开号：

  EP1829869A1

文献信息

• 4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE DERIVATIVES AND THEIR USE AS SIGMA RECEPTOR LIGANDS
  申请人：Corbera-Arjona Jordi

  公开号：US20090221572A1

  公开（公告）日：2009-09-03

  The present invention relates to compounds having pharmacological activity towards the sigma (σ) receptor, and more particularly to some 4, 5, 6, 7 tetrahydrobenzo[b]thiophene derivatives, wherein n is selected from 0, 1, 2, 3 or 4; m is selected from 0, 1 or 2; the dotted line represents either a single or a double bond; to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and prophylaxis, in particular for the treatment of psychosis.

  本发明涉及具有对σ受体具有药理活性的化合物，更具体地涉及一些4，5，6，7-四氢苯并[b]噻吩衍生物，其中n从0，1，2，3或4中选择；m从0，1或2中选择；虚线表示单键或双键；涉及制备这些化合物的过程，包括它们的药物组成物，以及它们在治疗和预防中的使用，特别是用于治疗精神病。
• Amidino substituted tetrahydrobenzo thiophene or furan derivatives and their use as urokinase inhibitors
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US06274619B1

  公开（公告）日：2001-08-14

  A compound of the formula: in which R1 is hydrogen, optionally substituted lower alkylcarbamoyl(lower)alkylidene, lower alkylidene, lower alkyl, optionally substituted ar(lower)alkyl, cyclo(lower)alkyl(lower)alkyl, protected carboxy(lower)alkyl, carboxy(lower)alkyl, hydroxy(lower)alkyl, optionally substituted lower alkylcarbamoyl(lower)alkyl, lower alkylthio(lower)alkyl, carboxy(lower)alkanoyl, protected carboxy(lower)alkanoyl, aroyl, lower alkanoyl, or optionally substituted arylcarbamoyl(lower)alkyl, R2 is hydrogen, carboxy, protected carboxy, formyl or N-(lower)alkyl-N-(lower)alkoxycarbamoyl, R3 is hydrogen or amidino-protective group, A is lower alkylene or carbonyl, X is Y is lower alkylene, —S— or —SO2—, Z is —S— or —O—, and the line: is a single bond or a double bond, or pharmaceutically acceptable salts thereof, which is useful as a medicament.

  一种化合物的化学式：其中，R1是氢，可选择性地取代下游戊二酰胺基（下）烷基亚烷基，下游烷基亚烷基，下游烷基，可选择性地取代芳基（下）烷基，环（下）烷基（下）烷基，保护羧基（下）烷基，羧基（下）烷基，羟基（下）烷基，可选择性地取代下游脲基（下）烷基，下游硫代（下）烷基，羧基（下）烷酰基，保护羧基（下）烷酰基，芳酰基，下游烷酰基，或可选择性地取代芳基脲基（下）烷基，R2是氢，羧基，保护羧基，甲酰基或N-（下）烷基-N-（下）烷氧基羰基，R3是氢或氨基保护基，A是下游亚烷基或羰基，X是Y是下游亚烷基，-S-或-SO2-，Z是-S-或-O-，线：是单键或双键，或其药学上可接受的盐，用作药物。
• Benzothiophene derivatives, their preparation and use as urokinase
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US06093710A1

  公开（公告）日：2000-07-25

  A compound of the formula ##STR1## in which R.sup.1 is hydrogen, lower alkyl, optionally substituted ar(lower)alkyl, cyclo(lower)alkyl(lower)alkyl, protected carboxy)lower)alkyl, carboxy)lower)alkyl, hydroxy(lower)alkyl, optionally substituted lower alkylcarbamoyl(lower)alkyl, lower alkylthio(lower)alkyl, carboxy(lower)alkanoyl, protected carboxy(lower)alkanoyl, aroyl, lower alkanoyl, or optionally substituted arylcarbamoyl(lower)alkyl, R.sup.2 is hydrogen, carboxy, protected carboxy, formyl or N-(lower)alkyl-N-(lower)alkoxycarbamoyl, R.sup.3 is hydrogen or amidino-protective group, A is lower alkylene or carbonyl, X is ##STR2## Y is --S-- or --SO.sub.2 --, Z is --S-- or --O--, or pharmaceutically acceptable salts thereof which is useful as a medicament.

  该化合物的化学式为##STR1##其中R.sup.1是氢、低烷基、可选择取代的芳基(低)烷基、环(低)烷基(低)烷基、保护羧基(低)烷基、羧基(低)烷基、羟基(低)烷基、可选择取代的低烷基氨甲酰(低)烷基、低烷基硫(低)烷基、羧基(低)烷酰、保护羧基(低)烷酰、芳酰基、低烷酰基或可选择取代的芳基氨甲酰(低)烷基，R.sup.2是氢、羧基、保护羧基、甲酰或N-(低)烷基-N-(低)烷氧基甲酰基，R.sup.3是氢或酰胺基保护基，A是低烷基或羰基，X是##STR2## Y是--S--或--SO.sub.2 --，Z是--S--或--O--，或其药学上可接受的盐，可用作药物。
• 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands
  申请人：Laboratorios del Dr. Esteve, S.A.

  公开号：US08227625B2

  公开（公告）日：2012-07-24

  The present invention relates to compounds having pharmacological activity towards the sigma (σ) receptor, and more particularly to some 4,5,6,7 tetrahydrobenzo[b]thiophene derivatives, wherein n is selected from 0, 1, 2, 3 or 4; m is selected from 0, 1 or 2; the dotted line represents either a single or a double bond; to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and prophylaxis, in particular for the treatment of psychosis.

  本发明涉及具有对sigma (σ)受体具有药理活性的化合物，更具体地涉及一些4,5,6,7-四氢苯并[b]噻吩衍生物，其中n选择从0、1、2、3或4中选择；m选择从0、1或2中选择；虚线表示单键或双键；制备这种化合物的方法，包括它们的制药组合物，以及它们在治疗和预防中的用途，特别是用于治疗精神病。
• 4,5,6,7-tetrahydrobenzo[B]thiophene derivatives and their use as sigma receptor ligands
  申请人：Corbera-Arjona Jordi

  公开号：US08492563B2

  公开（公告）日：2013-07-23

  The present invention relates to compounds having pharmacological activity towards the sigma (σ) receptor, and more particularly to some 4, 5, 6, 7 tetrahydrobenzo[b]thiophene derivatives, wherein n is selected from 0, 1, 2, 3 or 4; m is selected from 0, 1 or 2; the dotted line represents either a single or a double bond; to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and prophylaxis, in particular for the treatment of psychosis.

  本发明涉及对σ受体具有药理活性的化合物，更具体地涉及一些4、5、6、7-四氢苯并[b]噻吩衍生物，其中n从0、1、2、3或4中选择；m从0、1或2中选择；虚线表示单键或双键；涉及制备这些化合物的方法，包括它们的制药组合物以及它们在治疗和预防中的使用，特别是用于治疗精神病。