N-(2-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-5-morpholinophenyl)sulfamide | 1166389-61-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-(2-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-5-morpholinophenyl)sulfamide
• 英文别名: 4-[4-[[5-Fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-3-(sulfamoylamino)phenyl]morpholine
• CAS: 1166389-61-2
• 化学式: C₂₃H₂₈FN₇O₆S
• 分子量: 549.583
• InChiKey: WDIKFETTWUOMOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  38
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  171
• 氢给体数：
  4
• 氢受体数：
  14

文献信息

• SULFAMIDES AS ZAP-70 INHIBITORS
  申请人：Harrison Richard John

  公开号：US20110028405A1

  公开（公告）日：2011-02-03

  The invention relates to compounds of formula (I) wherein X, R 1 , R 2 , R 3 , R 8 , R 9 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of ZAP-70 for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

  本发明涉及式(I)的化合物，其中X、R1、R2、R3、R8、R9的含义如说明书和权利要求中所述。所述化合物可用作ZAP-70的抑制剂，用于治疗或预防免疫、炎症、自身免疫、过敏性疾病和免疫介导疾病。本发明还涉及包括所述化合物的制药组合物，以及用作药物的制备和使用。
• [EN] SULFAMIDES AS ZAP-70 INHIBITORS<br/>[FR] SULFAMIDES EN TANT QU'INHIBITEURS DE ZAP-70
  申请人：CELLZOME LTD

  公开号：WO2009080638A2

  公开（公告）日：2009-07-02

  The invention relates to compounds of formula (I). Said compounds are useful as inhibitors of ZAP-70 for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immuno logically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.