2-((3-Bromo-2-fluorophenoxy)methyl)oxirane | 1240725-64-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-((3-Bromo-2-fluorophenoxy)methyl)oxirane
• 英文别名: 2-[(3-bromo-2-fluorophenoxy)methyl]oxirane
• CAS: 1240725-64-7
• 化学式: C₉H₈BrFO₂
• 分子量: 247.06
• InChiKey: ALUKSHASDNTFSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  21.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO<br/>[FR] MODULATEURS DU RÉCEPTEUR ADRÉNERGIQUE BÊTA 3 UTILE DANS LE TRAITEMENT OU LA PRÉVENTION DE TROUBLES ASSOCIÉS À CEUX-CI
  申请人：ARENA PHARM INC

  公开号：WO2017214002A1

  公开（公告）日：2017-12-14

  The present invention relates to compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the beta-3 adrenergic receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of a beta-3 adrenergic receptor-mediated disorder, such as, heart failure; cardiac performance in heart failure; mortality, reinfarction, and/or hospitalization in connection with heart failure; acute heart failure; acute decompensated heart failure; congestive heart failure; severe congestive heart failure; organ damage associated with heart failure (e.g., kidney damage or failure, heart valve problems, heart rhythm problems, and/or liver damage); heart failure due to left ventricular dysfunction; heart failure with normal ejection fraction; cardiovascular mortality following myocardial infarction; cardiovascular mortality in patients with left ventricular failure or left ventricular dysfunction; left ventricular failure; left ventricular dysfunction; class II heart failure using the New York Heart Association (NYHA) classification system; class III heart failure using the New York Heart Association (NYHA) classification system; class IV heart failure using the New York Heart Association (NYHA) classification system; LVEF < 40% by radionuclide ventriculography; LVEF ≤35% by echocardiography or ventricular contrast angiography; and conditions related thereto.

  本发明涉及式(Ia)化合物及其调节β-3肾上腺素能受体活性的药物组合物。本发明的化合物及其药物组合物针对治疗β-3肾上腺素能受体介导的疾病的方法，例如心力衰竭；心力衰竭中的心脏功能；与心力衰竭相关的死亡率、再梗死和/或住院；急性心力衰竭；急性失代偿性心力衰竭；充血性心力衰竭；重度充血性心力衰竭；与心力衰竭相关的器官损伤（例如肾损伤或衰竭、心脏瓣膜问题、心律问题和/或肝损伤）；因左室功能障碍引起的心力衰竭；射血分数正常的心力衰竭；心肌梗死后心血管死亡率；左室衰竭或左室功能障碍患者的心血管死亡率；左室衰竭；左室功能障碍；纽约心脏协会（NYHA）分类系统的II级心力衰竭；纽约心脏协会（NYHA）分类系统的III级心力衰竭；纽约心脏协会（NYHA）分类系统的IV级心力衰竭；放射性核素心室造影LVEF<40%；超声心动图或心室对比血管造影LVEF≤35%；以及相关病症。
• Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto
  申请人：Arena Pharmaceuticals, Inc.

  公开号：US10479797B2

  公开（公告）日：2019-11-19

  The present invention relates to compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the beta-3 adrenergic receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of a beta-3 adrenergic receptor-mediated disorder, such as, heart failure; cardiac performance in heart failure; mortality, reinfarction, and/or hospitalization in connection with heart failure; acute heart failure; acute decompensated heart failure; congestive heart failure; severe congestive heart failure; organ damage associated with heart failure (e.g., kidney damage or failure, heart valve problems, heart rhythm problems, and/or liver damage); heart failure due to left ventricular dysfunction; heart failure with normal ejection fraction; cardiovascular mortality following myocardial infarction; cardiovascular mortality in patients with left ventricular failure or left ventricular dysfunction; left ventricular failure; left ventricular dysfunction; class II heart failure using the New York Heart Association (NYHA) classification system; class III heart failure using the New York Heart Association (NYHA) classification system; class IV heart failure using the New York Heart Association (NYHA) classification system; LVEF<40% by radionuclide ventriculography; LVEF≤35% by echocardiography or ventricular contrast angiography; and conditions related thereto.

  本发明涉及调节β-3肾上腺素能受体活性的式(Ia)化合物及其药物组合物。本发明的化合物及其药物组合物用于治疗β-3肾上腺素能受体介导的疾病，如心力衰竭；心力衰竭时的心脏表现；与心力衰竭有关的死亡率、再梗塞和/或住院治疗；急性心力衰竭；急性失代偿性心力衰竭；充血性心力衰竭；严重充血性心力衰竭；与心力衰竭有关的器官损伤（如：肾脏损伤或衰竭、心脏瓣膜问题、心律问题等）、左心室功能不全导致的心力衰竭；射血分数正常的心力衰竭；心肌梗塞后的心血管死亡率；左心室功能不全或左心室功能障碍患者的心血管死亡率；左心室功能不全；左心室功能障碍；根据纽约心脏协会（NYHA）分类系统划分的Ⅱ级心力衰竭；根据纽约心脏协会（NYHA）分类系统划分的Ⅲ级心力衰竭；根据纽约心脏协会（NYHA）分类系统划分的Ⅳ级心力衰竭；根据放射性核素心室造影检查，LVEF<40%；根据超声心动图或心室造影血管造影检查，LVEF≤35%；以及与此相关的情况。
• MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO
  申请人：Arena Pharmaceuticals, Inc.

  公开号：EP3464292A1

  公开（公告）日：2019-04-10