5-[1-[10-(3-N,N-Dimethylaminopropyl)phenothiazine-2-yl]-1-methyl]-ethyl-1H-tetrazole | 101184-63-8

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 5-[1-[10-(3-N,N-Dimethylaminopropyl)phenothiazine-2-yl]-1-methyl]-ethyl-1H-tetrazole
• 英文别名: N,N-dimethyl-3-[2-[2-(2H-tetrazol-5-yl)propan-2-yl]phenothiazin-10-yl]propan-1-amine
• CAS: 101184-63-8
• 化学式: C₂₁H₂₆N₆S
• 分子量: 394.544
• InChiKey: YLGPEPHWAYKVSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  86.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Phenothiazine compounds
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0163551A1

  公开（公告）日：1985-12-04

  The present invention relates to compounds of the formula (I): or a salt, ester or amide thereof; wherein R' is a C1-7 bivalent aliphatic hydrocarbon group or a single bond; R2 and R3 are the same or different and are each hydrogen, C1-4 alkyl or taken together with the nitrogen comprise a nitrogen-containing heterocyclic ring having four to six ring members; R4 is hydrogen, halogen, C1-4 alkoxy, C1-4, alkyl optionallyu substituted by one to three halogen atoms; or a group R, C02H as hereinbefore defined; and A is C1-4 alkylene orANR2R3forms a group -CH2-(CH2)2 or CH2-CH2)2 B is an acidic group other than a mono-carboxylic acid group of comparable or greater acid strength than a carboxylic acid group in a similar chemical environment, provided that any sulphonamide group contains at least one N-H bond. Also disclosed are processes for the preparation of. the compounds of the formula (I), chemical intermediates for use in their preparation, and pharmaceutical formulations containing the said compounds. The compounds have antiallergic activity as defined by blockade of anaphylactoid activity. Certain of the compounds also have good antihistaminic activity.

  本发明涉及式（I）化合物： 或其盐、酯或酰胺；其中 R' 是 C1-7 二价脂族烃基或单键； R2 和 R3 相同或不同，各自为氢、 C1-4烷基或与氮一起组成具有四至六个环成员的含氮杂环； R4 是氢、卤素、C1-4 烷氧基、任选被 1 至 3 个卤素原子取代的 C1-4 烷基或前文定义的基团 R、C02H；以及 A 是 C1-4 亚烷基或 ANR2R3 构成基团-CH2-( )2 或 - )2 B 是酸性基团，但不是酸性强度与类似化学环境中的羧酸基团相当或更大的一元羧酸基团，条件是任何磺酰胺基团至少含有一个 N-H 键。 还公开了制备式（I）化合物的工艺、用于制备的化学中间体以及含有上述化合物的药物制剂。 这些化合物具有抗过敏活性，具体表现为阻断过敏反应活性。某些化合物还具有良好的抗组胺活性。
• US4705854A
  申请人：——

  公开号：US4705854A

  公开（公告）日：1987-11-10