(2R.3S)-2.3-Dimethyl-pentansaeureamid | 13127-00-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2R.3S)-2.3-Dimethyl-pentansaeureamid
• 英文别名: threo-(3S)-2,3-Dimethyl-valeriansaeureamid；threo-2,3-Dimethyl-valeriansaeureamid；(2R,3S)-2,3-dimethylpentanamide
• CAS: 13127-00-9
• 化学式: C₇H₁₅NO
• 分子量: 129.202
• InChiKey: HRBAJVQRJUTNMM-NTSWFWBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• METHODS OF TREATING CANCER WITH TUBULYSIN CONJUGATES
  申请人：Endocyte, Inc.

  公开号：US20170290878A1

  公开（公告）日：2017-10-12

  The invention described herein pertains to drug delivery conjugates for targeted therapy. The invention described herein relates to methods of treating folate receptor-expressing cancers with a folate-tubulysin conjugate. The invention described herein also relates to methods of treating folate-expressing cancers with a folate tubulysin conjugate in patients where stable disease results after treatment with the folate-tubulysin conjugate.