2-(4-chlorophenoxymethyl)-1-indan-5-yl-piperazine | 1119697-76-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-(4-chlorophenoxymethyl)-1-indan-5-yl-piperazine
• 英文别名: 2-[(4-chlorophenoxy)methyl]-1-(2,3-dihydro-1H-inden-5-yl)piperazine
• CAS: 1119697-76-5
• 化学式: C₂₀H₂₃ClN₂O
• 分子量: 342.868
• InChiKey: WIXSJBXAAZXTAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  24.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• P2X4 RECEPTOR ANTAGONIST
  申请人：Sakuma Shogo

  公开号：US20110092703A1

  公开（公告）日：2011-04-21

  A P2X 4 receptor antagonist is a compound represented by the formula (I) or a pharmacologically acceptable salt thereof, which is used as a preventive or therapeutic agent for neuropathic pains: Wherein B is aryl or the like that can have a substituent; Y is C 1-5 alkylene that can have a double bond; Z is O, S or the like; each of R 1 , R 2 and R 3 independently is hydrogen, C 1-8 alkyl or the like; R 4 is hydrogen, C 1-8 alkyl or the like; each of P and Q independently is hydrogen, halogen, C 1-8 alkyl or the like; W is C 1-8 alkyl or the like; and each of n and m independently is 1 or 2.

  一种P2X4受体拮抗剂，其化学式表示为(I)，或其药理学上可接受的盐，可用作神经病理性疼痛的预防或治疗剂：其中，B是芳基或类似物，可以有取代基；Y是C1-5烷基，可以具有双键；Z是O、S或类似物；R1、R2和R3各自独立地是氢、C1-8烷基或类似物；R4是氢、C1-8烷基或类似物；P和Q各自独立地是氢、卤素、C1-8烷基或类似物；W是C1-8烷基或类似物；n和m各自独立地为1或2。
• PREVENTIVE OR THERAPEUTIC AGENT FOR PAIN ASSOCIATED WITH HERPES ZOSTER IN ACUTE PHASE
  申请人：Kyushu University

  公开号：EP2636414A1

  公开（公告）日：2013-09-11

  A P2X4 receptor antagonist such as paroxetine, a diazepinedione derivative having the following formula (IX) is used as an agent for preventing or treating zoster-associated pain in acute phase: wherein R1 is hydrogen, a C1-8 alkyl group, or the like; each of R2 and R3 is hydrogen, a C1-8 alkyl group, or the like; each of R4 and R5 is hydrogen or the like; and W is a five-membered or six-membered heterocyclic ring optionally having one or more substituents and comprising one to four nitrogen atoms as the members of the ring.

  P2X4 受体拮抗剂，如帕罗西汀，是一种具有下式（IX）的二氮杂环庚二酮衍生物，可用作预防或治疗急性期带状疱疹相关疼痛的药物： 其中 R1 是氢、C1-8 烷基或类似物； R2和R3各自为氢、C1-8烷基或类似物 R4 和 R5 分别为氢或类似物；以及 W 是五元或六元杂环，可选择具有一个或多个取代基，并包括一至四个氮原子作为环的成员。
• PROPHYLACTIC OR THERAPEUTIC AGENT FOR NEUROPATHIC PAIN ASSOCIATED WITH GUILLAIN-BARRE SYNDROME
  申请人：NIPPON CHEMIPHAR CO., LTD.

  公开号：US20140163013A1

  公开（公告）日：2014-06-12

  A P2X 4 receptor antagonist such as paroxetine, a diazepinedione derivative having the following formula (IX) is used as an agent for preventing or treating neuropathic pain associated with Guillain-Barré syndrome: wherein R 1 is hydrogen, a C 1-8 alkyl group, or the like; each of R 2 and R 3 is hydrogen, a C 1-8 alkyl group, or the like; each of R 4 and R 5 is hydrogen or the like; and W is a five-membered or six-membered heterocyclic ring optionally having one or more substituents and comprising one to four nitrogen atoms as the members of the ring.
• US9115123B2
  申请人：——

  公开号：US9115123B2

  公开（公告）日：2015-08-25
• US9561235B2
  申请人：——

  公开号：US9561235B2

  公开（公告）日：2017-02-07