Methyl propan-2-yl but-2-enedioate | 80652-48-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Methyl propan-2-yl but-2-enedioate
• 英文别名: 1-O-methyl 4-O-propan-2-yl but-2-enedioate
• CAS: 80652-48-8
• 化学式: C₈H₁₂O₄
• 分子量: 172.18
• InChiKey: WQIXPEFEGKBHTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• METHODS OF ADMINISTERING MONOMETHYL FUMARATE AND PRODRUGS THEREOF HAVING REDUCED SIDE EFFECTS
  申请人：XenoPort, Inc.

  公开号：US20150038499A1

  公开（公告）日：2015-02-05

  Methods of improving patient safety and reducing undesirable side effects for patients considering therapeutic treatment using monomethyl fumarate and prodrugs of monomethyl fumarate are disclosed. In particular, a method of treating a disease in a patient in need of such treatment is provided. The method comprises testing the patient for a propensity for a deficiency in tissue glutathione S-transferase theta 1 enzyme (GSTT1) levels. Thereafter, a therapeutically effective amount of a compound selected from monomethyl fumarate (MMF), a prodrug of monomethyl fumarate, and combinations thereof is administered to the patient. During the treatment of the disease, blood lymphocyte concentration is periodically tested in the patient at a predetermined time interval length that is based on the enzyme level propensity testing result.

  本发明涉及改善患者安全和减少治疗使用单甲基富马酸及其前药所产生的不良副作用的方法。具体而言，本发明提供了一种治疗患者疾病的方法。该方法包括对患者进行组织谷胱甘肽S-转移酶θ1酶（GSTT1）水平缺陷的倾向性测试。随后，向患者施用单甲基富马酸（MMF）、单甲基富马酸前药或其组合的治疗有效量。在治疗疾病期间，以基于酶水平倾向性测试结果的预定时间间隔长度定期检测患者的血淋巴细胞浓度。
• Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
  申请人：Arbor Pharmaceuticals, LLC

  公开号：US10945984B2

  公开（公告）日：2021-03-16

  Methods of reducing undesirable side effects during therapeutic treatment using monomethyl fumarate and prodrugs of monomethyl fumarate are disclosed.

  本研究公开了使用富马酸单甲酯和富马酸单甲酯原药在治疗过程中减少不良副作用的方法。
• Solid catalyst component for olefin polymerization and catalyst
  申请人：Hosaka Motoki

  公开号：US20050227856A1

  公开（公告）日：2005-10-13

  A solid catalyst component for polymerization of olefins prepared by contacting (a) a dialkoxy magnesium compound, (b) a tetra-valent titanium halide, and (c) an electron donor compound of the formula R 1 R 2 C(COOR 3 ) 2 suspended in (d) an aromatic hydrocarbon having a boiling point in the range of 50-150° C. The catalyst containing the catalyst component is excellent in the olefin polymerization catalyst activity to hydrogen and can produce a polymer with a high stereoregularity in a high yield.

  一种用于烯烃聚合的固体催化剂组分，其制备方法是将(a)二烷氧基镁化合物，(b)四价卤化钛，和(c)式 R 的电子供体化合物相接触 1 R 2 C(COOR 3 ) 2 含有该催化剂组分的催化剂对氢气的烯烃聚合催化活性极佳，并能以高产率生产出立体规整度高的聚合物。
• SOLID CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST
  申请人：TOHO TITANIUM CO., LTD.

  公开号：EP1533322B1

  公开（公告）日：2019-05-01
• ETHYLENE POLYMERIZATION CATALYSTS
  申请人：BASF Corporation

  公开号：EP2576633A2

  公开（公告）日：2013-04-10