methyl 4-(2-([2-((2-[(2-pentylcyclopropyl)methyl]cyclopropyl)methyl)cyclopropyl]methyl)cyclopropyl)butanoate | 56051-53-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 4-(2-([2-((2-[(2-pentylcyclopropyl)methyl]cyclopropyl)methyl)cyclopropyl]methyl)cyclopropyl)butanoate
• 英文别名: cyclopropanebutanoic acid,2-[[2-[[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]methyl]cyclopropyl]methyl]-, methyl ester；Cyclopropanebutanoic acid, 2-[[2-[[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]methyl]cyclopropyl]methyl]-, methyl ester；methyl 4-[2-[[2-[[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]methyl]cyclopropyl]methyl]cyclopropyl]butanoate
• CAS: 56051-53-7
• 化学式: C₂₅H₄₂O₂
• 分子量: 374.607
• InChiKey: FAQZFJDTUMBJQS-UHFFFAOYSA-N

物化性质

• 沸点：
  429.3±13.0 °C(Predicted)
• 密度：
  1.008±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  27
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] PKC ACTIVATORS AND COMBINATIONS THEREOF<br/>[FR] ACTIVATEURS DE PKC ET DES COMBINAISONS DE CEUX-CI
  申请人：BRNI NEUROSCIENCES INST

  公开号：WO2013071282A1

  公开（公告）日：2013-05-16

  The present disclosure relates to PKC activators and combinations thereof. The disclosure further relates to compositions, kits, uses, and methods thereof.

  本公开涉及PKC激活剂及其组合物。本公开进一步涉及其组成物、试剂盒、用途和方法。
• PKC ACTIVATORS AND COMBINATIONS THEREOF
  申请人：BLANCHETTE ROCKEFELLER NEUROSCIENCES INSTITUTE

  公开号：US20140315990A1

  公开（公告）日：2014-10-23

  The present disclosure relates to PKC activators and combinations thereof. The disclosure further relates to compositions, kits, uses, and methods thereof.

  本公开涉及PKC激活剂及其组合物。本公开进一步涉及其组成物、套件、用途和方法。
• PKC-activating compounds for the treatment of neurodegenerative diseases
  申请人：Cognitive Research Enterprises, Inc.

  公开号：US10323011B2

  公开（公告）日：2019-06-18

  The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.

  本发明涉及使用单不饱和脂肪酸和多不饱和脂肪酸的环丙烷化或环氧化衍生物激活蛋白激酶C（PKC）的一种同工酶，以治疗包括阿尔茨海默病和中风在内的神经系统疾病的方法。 本发明还涉及使用单不饱和和多不饱和脂肪酸的环丙烷化或环氧化衍生物减少神经变性的方法。
• ALZHEIMER'S DISEASE-SPECIFIC ALTERATIONS OF PROTEIN KINASE C EPSILON (PKC-EPSILON) PROTEIN LEVELS
  申请人：Blanchette Rockefeller Neurosciences Institute

  公开号：EP2539709A1

  公开（公告）日：2013-01-02
• PKC-Activating Compounds for the Treatment of Neurodegenerative Diseases
  申请人：Nelson Thomas J.

  公开号：US20100022645A1

  公开（公告）日：2010-01-28

  The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.