[1,4-bis(imidazol-1-yl)butane]bis[(pentafluorophenyl)gold(I)] | 1360077-37-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [1,4-bis(imidazol-1-yl)butane]bis[(pentafluorophenyl)gold(I)]
• CAS: 1360077-37-7
• 化学式: C₂₂H₁₄Au₂F₁₀N₄
• 分子量: 918.297
• InChiKey: PRHRXSFSFTXCOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  双咪唑丁烷 、 pentafluorophenyl(tetrahydrothiophene)gold(I) 以 四氢呋喃 、 甲醇 为溶剂， 以83%的产率得到[1,4-bis(imidazol-1-yl)butane]bis[(pentafluorophenyl)gold(I)]
  参考文献：
  名称：

  Neutral mononuclear and dinuclear complexes of gold(I) featuring azole ligands: Synthesis, structure and cytotoxicity

  摘要：

  The aim of this work was to extend the small library of existing compounds of gold(I) that contain pentafluorophenyl and thiazole ligands and to determine the biological activity of such compounds against a well-known cancer cell line. Seven mono and dinuclear new compounds that contain imidazole, thiazole and tetrazole rings were isolated and characterised. Three of the crystal structures determined indicated Au center dot center dot center dot Au interactions between constituent complex molecules. A simple adduct, [Au(C6F5)(N-methylimidazole)], exhibits a relatively high anti-tumour specificity indicating the viability of selected phosphine-free gold complexes as cytotoxic agents. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2011.12.026