申请人:Bhat Abhijit Suresh
公开号:US20120201809A1
公开(公告)日:2012-08-09
The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CLκ) comprising K
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according to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K
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, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety.
The invention further provides specific MAC compounds and compositions of the invention.