| 947538-05-8

• CAS: 947538-05-8
• 化学式: C₁₆H₃₃N₃O₄Si
• 分子量: 359.541
• InChiKey: PLXVLHJGTQENCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  γ-aminopropyl-3,7,10-trimethylsilatrane 、 异氰酸异丙酯 在 三乙胺 作用下， 以 甲苯 为溶剂， 生成
  参考文献：
  名称：

  Synthesis, Antitumor Activity, and SAR of N-Substituted γ-Aminopropylsilatrane Derivatives

  摘要：

  -Aminopropylsilatrane has been reported to possess biological activity against tumor cancer cells with low cytotoxicity in many kinds of silatranes. So some N-substituted -aminopropylsilatrane derivatives were synthesized and assayed by a primary anticancer screening against HT-29, Hela, and MDAMB435 cells by the use of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method. The structures of these derivatives were confirmed by H-1 NMR, electrospray ionization-mass spectrometry, and elemental analysis. The structure-activity relationship showed that the N-substituted derivatives exhibit better activity in which the -amino group of the silatrane is connected with stronger electron-withdrawing groups.

  DOI：

  10.1080/10426507.2013.829835