N-[2-(2-fluorophenyl)ethyl]-9H-dipyrido[2,3-b:4',3'-f]pyrimido[4,5-d]azepin-2-amine | 1246546-83-7

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: N-[2-(2-fluorophenyl)ethyl]-9H-dipyrido[2,3-b:4',3'-f]pyrimido[4,5-d]azepin-2-amine
• 英文别名: N-[2-(2-fluorophenyl)ethyl]-3,5,11,14,16-pentazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),2,4,6,8(13),9,11,16,18-nonaen-4-amine
• CAS: 1246546-83-7
• 化学式: C₂₂H₁₇FN₆
• 分子量: 384.416
• InChiKey: ZDZDRCFAYHXRFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS
  申请人：Tandon Manish

  公开号：US20100249108A1

  公开（公告）日：2010-09-30

  The present invention relates to substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及取代的二吡咯-嘧啶-二氮杂环化合物，取代的苯并-二吡咯-嘧啶-二氮杂环化合物以及合成这些化合物的方法。本发明还涉及含有取代的二吡咯-嘧啶-二氮杂环化合物，取代的苯并-二吡咯-嘧啶-二氮杂环化合物的药物组合物，并通过将这些化合物和药物组合物给予需要的受体中，治疗细胞增殖性疾病，如癌症的方法。
• USE OF METHYLNALTREXONE TO ATTENUATE TUMOR PROGESSION
  申请人：Salix Pharmaceuticals, Inc.

  公开号：EP3718404A1

  公开（公告）日：2020-10-07

  Presented herein are methods for preventing or treating tumor growth, tumor metastasis and/or abnormal proliferation of tumor cells in a subject, wherein the methods involve administration of a pharmaceutical composition comprising methylnaltrexone. Also presented herein are methods for inhibiting or slowing the growth of a tumor in a subject, wherein the methods include selecting a subject who is a suitable candidate for treatment with methylnaltrexone, and administering a composition comprising methylnaltrexone to the subject.

  本文提出了用于预防或治疗受试者体内肿瘤生长、肿瘤转移和/或肿瘤细胞异常增殖的方法，其中该方法涉及施用包含甲基纳曲酮的药物组合物。本文还提出了抑制或减缓受试者体内肿瘤生长的方法，其中所述方法包括选择适合使用甲基纳曲酮治疗的受试者，并向受试者施用包含甲基纳曲酮的组合物。
• Plant growth-promoting rhizobacteria infused fertilizer
  申请人：Nachurs Alpine Solutions

  公开号：US10059633B2

  公开（公告）日：2018-08-28

  The present invention is a plant fertilizer product comprising at least one organic potassium source and at least one bacillus strain of rhizobacteria.

  本发明是一种植物肥料产品，包含至少一种有机钾源和至少一种根瘤菌芽孢杆菌。
• Antimicrobial catheters
  申请人：Board of Regents, The University of Texas System

  公开号：US10744232B2

  公开（公告）日：2020-08-18

  Antimicrobial catheters and medical devices are provided. In some aspects, a low durometer aliphatic polyether polyurethane may be impregnated with a first antimicrobial agent (e.g., minocycline and rifampin) and coated with a second antimicrobial agent (e.g., chlorhexidine, gendine, or gardine). The antimicrobial catheters may display improved flexibility and resistance to kinking. Methods of producing the antimicrobial catheters are also provided.

  本文提供了抗菌导管和医疗器械。在某些方面，低硬度脂肪族聚醚聚氨酯可浸渍第一种抗菌剂（如米诺环素和利福平），并涂覆第二种抗菌剂（如洗必泰、腺嘌呤或腺嘌呤）。抗菌导管可显示出更好的柔韧性和抗扭结性。此外，还提供了生产抗菌导管的方法。
• Nanoparticle pharmaceutical delivery system
  申请人：ADEIRA PHARMA, LLC

  公开号：US11058778B2

  公开（公告）日：2021-07-13

  A method of preparing a nanoparticle pharmaceutical delivery system. A nanoparticle pharmaceutical delivery system. A method of preparing a targeted nanoparticle pharmaceutical delivery system. A targeted nanoparticle pharmaceutical delivery system.

  一种制备纳米颗粒给药系统的方法。一种纳米颗粒给药系统。一种靶向纳米颗粒给药系统的制备方法。一种靶向纳米颗粒给药系统。