N-Methyl[1-cyclohexylcarbamoyl-4-cyclohexylmeth yl-6-(S)-isobutyl-5-oxo-piperazin-2-yl]-acetamide | 439153-48-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Methyl[1-cyclohexylcarbamoyl-4-cyclohexylmeth yl-6-(S)-isobutyl-5-oxo-piperazin-2-yl]-acetamide
• 英文别名: (2S)-N-cyclohexyl-4-(cyclohexylmethyl)-6-[2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-3-oxopiperazine-1-carboxamide
• CAS: 439153-48-7
• 化学式: C₂₅H₄₄N₄O₃
• 分子量: 448.649
• InChiKey: BHYBNKSGIQVHCP-KEKNWZKVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  81.8
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Heterocycle derivatives as PPAR-gamma agonists
  申请人：——

  公开号：US20020082263A1

  公开（公告）日：2002-06-27

  Compounds having the structure 1 are peroxisome proliferator-activated receptor-gamma (PPAR-gamma) selective agonists and as such are useful in the modulation of blood glucose and the increase of insulin sensitivity in mammals. This activity of the piperazine derivatives of the invention make them particularly useful in the treatment of those conditions selected from the group consisting of diabetes, atherosclerosis, hyperglycemia, hyperlipidemia, obesity, syndrome X, insulin resistance, hypertension, heart failure and cardiovascular disease in mammals.

  具有结构1的化合物是过氧化物酶体增殖物激活受体-γ（PPAR-γ）选择性激动剂，因此在哺乳动物中调节血糖和增加胰岛素敏感性方面非常有用。发明的哌嗪衍生物具有这种活性，使它们特别适用于治疗糖尿病、动脉硬化、高血糖、高脂血症、肥胖症、综合征X、胰岛素抵抗、高血压、心力衰竭和心血管疾病等疾病。
• US6462046B2
  申请人：——

  公开号：US6462046B2

  公开（公告）日：2002-10-08
• [EN] HETEROCYCLE DERIVATIVES AS PPAR-GAMMA AGONISTS<br/>[FR] DERIVES HETEROCYCLIQUES EN TANT QU'AGONISTES PPAR-GAMMA
  申请人：ADVANCED SYNTECH LLC

  公开号：WO2002053546A1

  公开（公告）日：2002-07-11

  Compounds having the structure are peroxisome proliferator-activated receptor-gamma (PPAR-gamma) selective agonists and as such are useful in the modulation of blood glucose and the increase of insulin sensitivity in mammals. This activity of the piperazine derivatives of the invention make them particularly useful in the treatment of those conditions selected from the group consisting of diabetes, atherosclerosis, hyperglycemia, hyperlipidemia, obesity, syndrome X, insulin resistance, hypertension, heart failure and cardiovascular disease in mammals.