3-ethyl-4-methyl-2-(α-hydroxybenzyl)pyrrole-5-carboxylic acid | 168066-31-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3-ethyl-4-methyl-2-(α-hydroxybenzyl)pyrrole-5-carboxylic acid
• CAS: 168066-31-7
• 化学式: C₁₅H₁₇NO₃
• 分子量: 259.305
• InChiKey: PKAGQMFCODOEOD-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  3-ethyl-4-methyl-2-(α-hydroxybenzyl)pyrrole-5-carboxylic acid 、 cobalt(II) acetate 、 三苯基膦 在 sodium acetate 作用下， 以 乙醇 、 三氟乙酸 为溶剂， 以20%的产率得到[(triphenylphosphine)(5,10,15-triphenyl-2,7,12,17-tetramethyl-3,8,13,18-tetraethylcorrolato)cobalt(III)]
  参考文献：
  名称：

  The effect of steric hindrance in the synthesis of corrolates via the cobalt catalyzed cyclization of 2-(α-hydroxyalkyl)pyrroles

  摘要：

  2-(alpha-Hydroxyalkyl)pyrroles react in the presence of cobalt ions leading to the formation of corrolates or porphyrinates as a function of the 2-substituents. The nature of the cyclic tetrapyrrole obtained can be related to the steric hindrance of the substituent present in the starting pyrrole, The presence of cobalt ions is essential to drive the reaction towards the formation of the contracted corrole macroring. When 3-ethyl-4-methyl-2-(alpha-hydroxybenzyl)pyr acid is used as starting material an etio-like cobalt correlate, i.e. with alternate methyl and ethyl groups on the beta-pyrrolic positions, has been obtained as demonstrated by detailed analysis of the NMR spectrum of the complex, A possible reaction pathway explaining the formation of such a species is reported.

  DOI：

  10.1016/0020-1693(95)90040-d