5-chloro-N2-(2-methoxy-5-methyl-4-(oxazol-5-yl)phenyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine | 1202388-70-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-chloro-N2-(2-methoxy-5-methyl-4-(oxazol-5-yl)phenyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
• 英文别名: 5-chloro-2-N-[2-methoxy-5-methyl-4-(1,3-oxazol-5-yl)phenyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
• CAS: 1202388-70-2
• 化学式: C₁₉H₁₈ClN₇O₂
• 分子量: 411.851
• InChiKey: DZMYGPFESCEQGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS
  申请人：Marsilje Thomas H.

  公开号：US20110112096A1

  公开（公告）日：2011-05-12

  The invention provides novel pyrimidine derivatives of formula (I) and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-IR) or analplastic lymphoma kinase (ALK).

  本发明提供了式(I)的新型嘧啶衍生物及其制药组合物，以及使用这些化合物的方法。例如，本发明的嘧啶衍生物可用于治疗、改善或预防对胰岛素样生长因子（IGF-IR）或无形淋巴瘤激酶（ALK）的抑制有反应的疾病。
• US8445505B2
  申请人：——

  公开号：US8445505B2

  公开（公告）日：2013-05-21
• [EN] COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS<br/>[FR] COMPOSÉS ET COMPOSITIONS EN TANT QU'INHIBITEURS DE KINASE
  申请人：IRM LLC

  公开号：WO2009158431A2

  公开（公告）日：2009-12-30

  The invention provides novel pyrimidine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-1R) or analplastic lymphoma kinase (ALK).