2-(N-allyl-N-(3-(2-(2-(4-morpholinophenyl)-5-methyloxazol-4-yl)ethoxy)benzyl)amino)acetic acid ethyl ester | 530129-74-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2-(N-allyl-N-(3-(2-(2-(4-morpholinophenyl)-5-methyloxazol-4-yl)ethoxy)benzyl)amino)acetic acid ethyl ester
• 英文别名: Ethyl 2-[[3-[2-[5-methyl-2-(4-morpholin-4-ylphenyl)-1,3-oxazol-4-yl]ethoxy]phenyl]methyl-prop-2-enylamino]acetate
• CAS: 530129-74-9
• 化学式: C₃₀H₃₇N₃O₅
• 分子量: 519.641
• InChiKey: DCMOCYJTTXRGMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  38
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  77.3
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Carboxylic acid derivatives compounds and agents comprising the compounds as active ingredient
  申请人：——

  公开号：US20040254370A1

  公开（公告）日：2004-12-16

  A compound of formula (I) 1 (wherein all symbols are as defined in the specification) and a salt thereof, and peroxisome proliferator activated receptor regulator comprising thereof as active ingredient. Because a compound of formula (I) have an activity of regulating peroxisome proliferator activated receptor regulator, the compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or treatment agent for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, ischemic heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.

  一种化合物的化学式为(I)1（其中所有符号在说明书中定义），以及其盐，以其为活性成分的过氧化物酶增殖物激活受体调节剂。由于化合物(I)具有调节过氧化物酶增殖物激活受体调节剂的活性，因此化合物(I)可用作降糖剂、降脂剂、代谢紊乱（糖尿病、肥胖症、X综合症、高胆固醇血症、高脂蛋白血症等）相关疾病的预防和/或治疗剂，高脂血症、动脉硬化、高血压、循环系统疾病、暴饮暴食、缺血性心脏病等，以及提高HDL胆固醇水平的药物、降低LDL胆固醇和/或VLDL胆固醇的药物和缓解糖尿病或X综合症风险因素的药物。
• CARBOXYLIC ACID DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1445256A1

  公开（公告）日：2004-08-11

  A compound of formula (I) (wherein all symbols are as defined in the specification) and a salt thereof, and peroxisome proliferator activated receptor regulator comprising thereof as active ingredient. Because a compound of formula (I) have an activity of regulating peroxisome proliferator activated receptor regulator, the compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or treatment agent for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, ischemic heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.

  一种式 (I) (其中所有符号如说明书中所定义）及其盐，以及作为活性成分的过氧化物酶体增殖物激活受体调节剂。由于式（I）化合物具有调节过氧化物酶体增殖物激活受体调节剂的活性，因此式（I）化合物可用作降血糖剂、降血脂剂、代谢紊乱相关疾病（糖尿病、肥胖症、X 综合征、高胆固醇血症、高脂蛋白血症等）、高血脂症、动脉粥样硬化、高血压、循环系统疾病、暴饮暴食、缺血性心脏病等的预防和/或治疗剂、高密度脂蛋白胆固醇升高剂、低密度脂蛋白胆固醇和/或低密度脂蛋白胆固醇降低剂以及缓解糖尿病或 X 综合征危险因素的药物。
• US7323456B2
  申请人：——

  公开号：US7323456B2

  公开（公告）日：2008-01-29