L-Cystine, N,N'-bis(1-Oxooctyl)-, dimethyl ester | 139416-29-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Cystine, N,N'-bis(1-Oxooctyl)-, dimethyl ester
• 英文别名: methyl 3-[[3-methoxy-2-(octanoylamino)-3-oxopropyl]disulfanyl]-2-(octanoylamino)propanoate
• CAS: 139416-29-8
• 化学式: C₂₄H₄₄N₂O₆S₂
• 分子量: 520.8
• InChiKey: IABUADDNIJQRPX-UHFFFAOYSA-N

物化性质

• 沸点：
  677.2±55.0 °C(Predicted)
• 密度：
  1.102±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  34
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  161
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Inflammation Inhibitor Comprising Zinc Salt of Acylamino Acid
  申请人：Iwasaki Keiji

  公开号：US20070099888A1

  公开（公告）日：2007-05-03

  An inflammation inhibitor for the skin is provided containing a zinc salt of an acylamino acid and further, a cosmetic containing the inflammation inhibitor.

  提供了一种皮肤炎症抑制剂，其包含一种酰胺酸锌盐，此外还包括一种含有该炎症抑制剂的化妆品。
• EXTERNAL DERMAL COMPOSITION FOR ANTI-AGEING AND METHOD FOR PRODUCING THE SAME
  申请人：HAYASHIBARA CO., LTD.

  公开号：US20150342854A1

  公开（公告）日：2015-12-03

  The present invention has an object to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as wrinkles, fine wrinkles, blemishes, and saggings caused by increasing age or ageing; and maintains or improves the barrier function and the hyaluronic acid production in the skin. The object is solved by providing an external dermal composition for anti-ageing, which contains an aqueous medium as a base material and one or more ingredients selected from L-ascorbic acid, derivatives thereof, and their salts as an effective ingredient(s).

  本发明的目的是提供一种用于抗衰老的外用皮肤组成物，该组成物可以预防或改善因年龄增长或衰老引起的皮肤问题，如皱纹、细纹、斑点和下垂，并维持或改善皮肤的屏障功能和透明质酸的产生。本发明通过提供一种外用皮肤组成物来实现该目的，该组成物包含水性介质作为基材料，并含有一种或多种从L-抗坏血酸、其衍生物和它们的盐中选择的成分作为有效成分。
• NOVEL CYSTINE DERIVATIVES AND INHIBITORS FOR THE ACTIVATION OF INFLAMMATORY FACTORS
  申请人：Ajinomoto Co., Inc.

  公开号：EP1364943A1

  公开（公告）日：2003-11-26

  A novel cystine derivative of a specific structure, such as N,N'-bis(2-hydroxybenzyl)-L-cystine (which may be in any form of free form, salt, solvate and the like) has been found to have an excellent action to suppress the activation of inflammatory factors. By using the derivative as an effective ingredient, an excellent agent for suppressing the activation of inflammatory factors can be provided. Additionally, the cystine derivative is preferably used for a method for suppressing the activation of inflammatory factors (in particular a method for preventing, ameliorating and/or therapeutically treating diseases (disorders), or skin injuries or disorders involved in the activation of inflammatory factors, a method for preventing, delaying, ameliorating and/or therapeutically treating skin change via aging or aesthetically unfavorable skin change as induced or promoted by inflammatory factors, and the like) and for pharmaceutical agents (pharmaceutical products; external skin application agents, eye drops, nutrition agents, transfusion and the like), cosmetics, foods or drinks and the like which are specific use applications to the agent for suppressing the activation of inflammatory factors. The invention also provides the novel cystine derivative with the excellent action to suppress the activation of inflammatory factors, which can be used as the effective ingredient described above, and a method for producing the same, and additionally provides the method for suppressing the activation of inflammatory factors described above, a use of the cystine derivative (active ingredient) described above for the agent for suppressing the activation of inflammatory factors, and the like.

  研究发现，一种具有特定结构的新型胱氨酸衍生物，如 N,N'-双（2-羟基苄基）-L-胱氨酸（可以是游离态、盐、溶液等任何形式），在抑制炎症因子活化方面具有出色的作用。通过使用该衍生物作为有效成分，可以提供一种抑制炎症因子活化的极佳制剂。此外，胱氨酸衍生物优选用于抑制炎症因子活化的方法（特别是预防、改善和/或治疗涉及炎症因子活化的疾病（失调）或皮肤损伤或失调的方法，预防、延缓、改善和/或治疗由炎症因子诱发或促进的皮肤老化或美观上不利的皮肤变化的方法等）和药物制剂（医药产品；外用皮肤涂抹剂、眼药水、营养剂、输血等）、化妆品、食品或饮料等，这些都是抑制炎症因子活化的药剂的特定用途应用。 本发明还提供了具有良好抑制炎症因子活化作用、可用作上述有效成分的新型胱氨酸衍生物及其生产方法，此外还提供了上述抑制炎症因子活化的方法、上述胱氨酸衍生物（有效成分）在抑制炎症因子活化制剂中的用途等。
• PHARMACEUTICAL PREPARATION FOR EXTERNAL APPLICATION TO SKIN COMPRISING PHOSPHORYLATED SUGAR
  申请人：Ezaki Glico Co., Ltd.

  公开号：EP1932514A1

  公开（公告）日：2008-06-18

  Provided is an external preparation for skin, comprising a phosphorylated saccharide. The phosphorylated saccharide may be an inorganic salt of a phosphorylated saccharide. The phosphorylated saccharide may be a calcium, magnesium, potassium, zinc, iron or sodium salt. Also provided is an external preparation for skin, comprising a phosphorylated saccharide and a second component, wherein the second component is selected from the group consisting of moisturizing agents, whitening components, ultraviolet absorbents, anti-inflammatory agents, cell-activating agents and antioxidants. The moisturizing agent may be ascorbic acid or an ascorbic acid derivative.

  本文提供了一种皮肤外用制剂，其中包含一种磷酸化糖。磷酸化糖可以是磷酸化糖的无机盐。磷酸化糖可以是钙、镁、钾、锌、铁或钠盐。还提供了一种皮肤外用制剂，包括磷酸化糖和第二种成分，其中第二种成分选自保湿剂、美白成分、紫外线吸收剂、消炎剂、细胞活化剂和抗氧化剂组成的组。保湿剂可以是抗坏血酸或抗坏血酸衍生物。
• INFLAMMATION INHIBITOR COMPRISING ZINC SALT OF ACYLAMINO ACID
  申请人：Ajinomoto Co., Inc.

  公开号：EP2111860A1

  公开（公告）日：2009-10-28

  An object is to provide an inflammation inhibitor which gives a good feeling of use. The inflammation inhibitor for the skin characterized by comprising a zinc salt of an acylamino acid is provided and further, a cosmetic characterized by containing the inflammation inhibitor is provided.

  目的是提供一种使用感良好的炎症抑制剂。 本发明提供了一种皮肤炎症抑制剂，其特征在于包含一种酰氨基锌盐，此外，还提供了一种化妆品，其特征在于含有该炎症抑制剂。