7-[(1R,2S)-2-[(E)-3-hydroxyoct-1-enyl]-5-oxocyclopent-3-en-1-yl]heptanoic acid | 801167-90-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-[(1R,2S)-2-[(E)-3-hydroxyoct-1-enyl]-5-oxocyclopent-3-en-1-yl]heptanoic acid
• CAS: 801167-90-8
• 化学式: C₂₀H₃₂O₄
• 分子量: 336.472
• InChiKey: BGKHCLZFGPIKKU-XBUWFATQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• CLOSANTEL IN COMBINATION WITH TEMOZOLOMIDE FOR USE IN THE TREATMENT OF A CANCER IN WHICH IS THYMINE DNA GLYCOSYLASE EXPRESSED
  申请人：Institute For Cancer Research D/b/a The Research Institute of Fox Chase Cancer Center

  公开号：EP3052655B1

  公开（公告）日：2018-11-07
• Inhibition of Thymine DNA Glycosylase in the Treatment of Cancer
  申请人：Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center

  公开号：US20220054500A1

  公开（公告）日：2022-02-24

  The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine DNA glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine DNA glycosylase in cancer cells. Inhibition of thymine DNA glycosylase in cancer cells may induce the cells to revert to a healthy, non-cancerous phenotype and/or may induce the cells to senesce. Cancer cells include melanoma, lung, prostate, pancreatic, ovarian, brain, colon, recto-sigmoid colon, and breast cancer cells.
• US5877215A
  申请人：——

  公开号：US5877215A

  公开（公告）日：1999-03-02