(4-(dimethylamino)benzyl)triphenylphosphonium chloride | 115032-56-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-(dimethylamino)benzyl)triphenylphosphonium chloride
• 英文别名: [4-(Dimethylamino)phenyl]methyl-triphenylphosphanium;chloride
• CAS: 115032-56-9
• 化学式: C₂₇H₂₇NP*Cl
• 分子量: 431.945
• InChiKey: GTAJIHPSOSAOAG-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.25
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-<2-(4-Formylphenyl)ethenyl>benzenesulfonamide 、 (4-(dimethylamino)benzyl)triphenylphosphonium chloride 在 乙醇锂 作用下， 以 乙醇 为溶剂， 反应 48.0h， 以43%的产率得到4-<2-<4-<2-<4-(dimethylamino)phenyl>ethenyl>phenyl>ethenyl>benzenesulfonamide
  参考文献：
  名称：

  高度极化低聚（亚苯基亚乙烯基）衍生物的单层和 LB 薄膜

  摘要：

  合成了高度极化的低聚（亚苯基亚乙烯基）两亲物，并检查了它们的单层性质。相应的 Langmuir-Blodgett 薄膜产生光学二次谐波。

  DOI：

  10.1246/cl.1991.905
• 作为产物：
  描述：

  对二甲氨基苯甲醛 在 盐酸 、 甲醇 、 sodium tetrahydroborate 作用下， 以 二氯甲烷 为溶剂， 反应 26.0h， 生成 (4-(dimethylamino)benzyl)triphenylphosphonium chloride
  参考文献：
  名称：

  强效秋水仙碱位点配体中三甲氧基苯环的新型氨基类似物通过掩蔽极性基团掺入 (MPGI) 策略提高溶解度

  摘要：

  秋水仙碱位点抗有丝分裂剂的低水溶性是其临床开发中的一个严重缺陷，其中三甲氧基苯基（A 环）是重要的贡献者。我们设计了新的 A 环类似物，其具有变色龙掩蔽的极性氨基，能够增加水溶性，并且在与微管蛋白结合时通过分子内氢键表现得非极性。我们已将这些新的 A 环整合到几种支架（磺胺类药物、combretastatins、phenstatins、isocombretastatins）中，合成并分析了 43 个代表。氨基类似物显示出改善的水溶性，其中一些（8、60 Z和67) 对人类癌细胞系的纳摩尔抗增殖效力，最有利的取代基是 3-甲基氨基。抗增殖作用与微管蛋白抑制有关，如体外微管蛋白聚合抑制、免疫荧光显微镜检查以及流式细胞术的细胞周期和细胞凋亡分析所示。这些化合物会阻止 G 2中处理过的细胞的细胞周期/M 并随后发展出凋亡反应。对接研究表明在微管蛋白的秋水仙碱位点结合，与新结构变异的 DFT 模型非常一致。3-methylamino-4

  DOI：

  10.1016/j.bioorg.2022.106282

文献信息

• SILICON-CONTAINING PARTICLE, PROCESS FOR PRODUCING THE SAME, ORGANIC-POLYMER COMPOSITION, CERAMIC, AND PROCESS FOR PRODUCING THE SAME
  申请人：Dow Corning Toray Co., Ltd.

  公开号：EP2241586A1

  公开（公告）日：2010-10-20

  A process for producing silicon-containing particles having an extremely small particle diameter by a simple process without using surface-active agents or the like. The process is characterized by forming silicon-containing particles as a result of phase separation from an organic polymer, wherein the phase separation is achieved by an addition reaction, condensation reaction, ring-opening reaction, or a radical reaction of a curable silicon-containing compound or a curable composition that contains said compound, and the silicon-containing compound or the composition is maintained in a uniform liquid, fused, or dissolved phase with the organic polymer that is free of silicon and does not participate in the curing reaction of the silicon-containing compound or the composition.

  一种不使用表面活性剂等，通过简单工艺生产具有极小颗粒直径的含硅颗粒的工艺。该工艺的特点是通过与有机聚合物的相分离形成含硅颗粒，其中相分离是通过可固化的含硅化合物或含有所述化合物的可固化组合物的加成反应、缩合反应、开环反应或自由基反应实现的，含硅化合物或组合物与有机聚合物保持在均匀的液相、熔融相或溶解相中，有机聚合物不含硅、不参与含硅化合物或组合物的固化反应。
• SILICON-CONTAINING PARTICLES, METHOD FOR MANUFACTURING THEREOF, OIL COMPOSITION, CERAMIC MATERIAL, AND METHOD FOR MANUFACTURING THEREOF
  申请人：Dow Corning Toray Co., Ltd.

  公开号：EP2271702A2

  公开（公告）日：2011-01-12
• Silicon-Containing Particles, Method For Manufacturing Thereof, Oil Composition, Ceramic Material, And Method For Manufacturing Thereof
  申请人：Harimoto Yukinari

  公开号：US20110045963A1

  公开（公告）日：2011-02-24

  This invention relates to a method for manufacturing silicon-containing particles characterized by preparing a uniform phase comprising a curable composition that includes a silicon-containing compound having in one molecule one or more reactive functional groups per 50 silicon atoms and an oil that does not participate in curing of the composition, then curing the composition, and causing phase separation from the oil for obtaining the silicon-containing particles; and to silicon-containing particles obtained by the above method. The method provides silicon-containing particles of an extremely small diameter in a simple process without the use of surfactants. And the silicon-containing particles possess excellent dispersibility in oil and a high degree of ceramification by baking.
• Silicon-Containing Particle, Process For Producing The Same, Organic-Polymer Composition, Ceramic, And Process For Producing The Same
  申请人：Harimoto Yukinari

  公开号：US20110033708A1

  公开（公告）日：2011-02-10

  A process for producing silicon-containing particles having an extremely small particle diameter by a simple process without using surface-active agents or the like. The process is characterized by forming silicon-containing particles as a result of phase separation from an organic polymer, wherein the phase separation is achieved by an addition reaction, condensation reaction, ring-opening reaction, or a radical reaction of a curable silicon-containing compound or a curable composition that contains said compound, and the silicon-containing compound or the composition is maintained in a uniform liquid, fused, or dissolved phase with the organic polymer that is free of silicon and does not participate in the curing reaction of the silicon-containing compound or the composition.
• US8450231B2
  申请人：——

  公开号：US8450231B2

  公开（公告）日：2013-05-28