tert-butyl [(2S)-1-{[bis(4-methoxybenzyl)carbamoyl]oxy}hexan-2-yl]carbamate | 1378533-40-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: tert-butyl [(2S)-1-{[bis(4-methoxybenzyl)carbamoyl]oxy}hexan-2-yl]carbamate
• 英文别名: [(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexyl] N,N-bis[(4-methoxyphenyl)methyl]carbamate
• CAS: 1378533-40-4
• 化学式: C₂₈H₄₀N₂O₆
• 分子量: 500.635
• InChiKey: WWJADNNQMXWKBM-QHCPKHFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  36
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  86.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• COMPOSITIONS AND METHODS TO IMPROVE THE HOMING AND GRAFTING OF HEMATOPOETIC STEM CELLS
  申请人：7 HILLS INTERESTS, LLC

  公开号：EP3104867A1

  公开（公告）日：2016-12-21
• [EN] COMPOSITIONS AND METHODS TO IMPROVE THE HOMING AND GRAFTING OF HEMATOPOETIC STEM CELLS<br/>[FR] COMPOSITIONS ET PROCÉDÉS D'AMÉLIORATION DE LA NOSTOCYTOSE ET LA PRISE DE GREFFE DE CELLULES SOUCHES HÉMATOPOÏÉTIQUES
  申请人：HILLS PHARMA LLC 7

  公开号：WO2015123447A1

  公开（公告）日：2015-08-20

  Media compositions and methods of enhancing binding of cells to an integrin-binding ligand comprising treating integrin-expressing hematopoietic stem cells ex vivo with an agonist of integrin, wherein the integrin is selected from the group consisting of 4 1, 5 1, 4 7, v 3 and L 2, and contacting the treated cells ex vivo with an integrin-binding ligand; integrin agonist compounds having the general formula I; methods of treating integrin-expressing cells with such agonists to enhance binding; and therapeutic methods comprising administering agonist-treated cells with minimal exposure agonist compounds to a mammal requiring stem cell transplantation in the management of hematologic cancers and genetic diseases.