Tert-butyl 2-[4-[[bis[[1-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]triazol-4-yl]methyl]amino]methyl]triazol-1-yl]acetate | 632330-01-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Tert-butyl 2-[4-[[bis[[1-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]triazol-4-yl]methyl]amino]methyl]triazol-1-yl]acetate
• CAS: 632330-01-9
• 化学式: C₂₇H₄₂N₁₀O₆
• 分子量: 602.694
• InChiKey: WGDOMMWHAXZOOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  43
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  174
• 氢给体数：
  0
• 氢受体数：
  13

文献信息

• Copper-catalysed ligation of azides and acetylenes
  申请人：Sharpless K. Barry

  公开号：US20110105764A1

  公开（公告）日：2011-05-05

  A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. The source of reactive Cu(I) ion can be, for example, a Cu(I) salt or copper metal. The process is preferably carried out in a solvent, such as an aqueous alcohol. Optionally, the process can be performed in a solvent that comprises a ligand for Cu(I) and an amine.