5-(Hydroxymethyl)-4-[(2-hydroxy-5-nitrophenyl)iminomethyl]-2-methylpyridin-3-ol | 1401430-60-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-(Hydroxymethyl)-4-[(2-hydroxy-5-nitrophenyl)iminomethyl]-2-methylpyridin-3-ol
• CAS: 1401430-60-1
• 化学式: C₁₄H₁₃N₃O₅
• 分子量: 303.274
• InChiKey: UBULKXICIIVMKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  132
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5-(Hydroxymethyl)-4-[(2-hydroxy-5-nitrophenyl)iminomethyl]-2-methylpyridin-3-ol 、 二丁基二氯化锡 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以69%的产率得到Dibutyltin(2+);5-(hydroxymethyl)-2-methyl-4-[(5-nitro-2-oxidophenyl)iminomethyl]pyridin-3-olate
  参考文献：
  名称：

  Bioactive Penta-Coordinated Diorganotin(Iv) Complexes of Pyridoxalimine Schiff Bases

  摘要：

  Diorganotin(IV) complexes of an extended system derived from the condensation of pyridoxal hydrochloride with 2-amino phenol (H2L1), 2-amino-4-methyl phenol (H2L2), 2-amino-4-chloro phenol (H2L3), 2-amino-4-nitro phenol (H2L4), 1-amino-2-naphthol hydrochloride (H2L5) have been synthesized by the reaction of dichlorodiorganotin(IV) in a 1:1 molar ratio with these ligands. Spectral studies (IR, H-1, C-13, Sn-119 NMR) along with physical data evidenced the formation of penta-coordinated species with the ligands acting as tridentate (ONO) with oxygen occupying the axial positions, and nitrogen at one of the equatorial positions. The ligands and their organotin complexes have been evaluated for antimicrobial activity against phytopathogenic fungi Candida albicans and Aspergillus niger at 25 +/- 1 degrees C and bacteria Bacillus subtilis, Escherichia coli, and Staphylococcus aureus at 37 +/- 1 degrees C. The activities of the ligands have been enhanced on complexation and the results indicate that they exhibit significant antimicrobial properties.

  DOI：

  10.1080/10426507.2012.692129
• 作为产物：
  描述：

  、 2-氨基-4-硝基苯酚 在 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 5-(Hydroxymethyl)-4-[(2-hydroxy-5-nitrophenyl)iminomethyl]-2-methylpyridin-3-ol
  参考文献：
  名称：

  Bioactive Penta-Coordinated Diorganotin(Iv) Complexes of Pyridoxalimine Schiff Bases

  摘要：

  Diorganotin(IV) complexes of an extended system derived from the condensation of pyridoxal hydrochloride with 2-amino phenol (H2L1), 2-amino-4-methyl phenol (H2L2), 2-amino-4-chloro phenol (H2L3), 2-amino-4-nitro phenol (H2L4), 1-amino-2-naphthol hydrochloride (H2L5) have been synthesized by the reaction of dichlorodiorganotin(IV) in a 1:1 molar ratio with these ligands. Spectral studies (IR, H-1, C-13, Sn-119 NMR) along with physical data evidenced the formation of penta-coordinated species with the ligands acting as tridentate (ONO) with oxygen occupying the axial positions, and nitrogen at one of the equatorial positions. The ligands and their organotin complexes have been evaluated for antimicrobial activity against phytopathogenic fungi Candida albicans and Aspergillus niger at 25 +/- 1 degrees C and bacteria Bacillus subtilis, Escherichia coli, and Staphylococcus aureus at 37 +/- 1 degrees C. The activities of the ligands have been enhanced on complexation and the results indicate that they exhibit significant antimicrobial properties.

  DOI：

  10.1080/10426507.2012.692129