1-(4-Fluorophenyl)-2-sulfanylidene-7-oxa-3-thia-1-azaspiro[4.4]nonan-8-one | 1309690-02-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-Fluorophenyl)-2-sulfanylidene-7-oxa-3-thia-1-azaspiro[4.4]nonan-8-one
• CAS: 1309690-02-5
• 化学式: C₁₂H₁₀FNO₂S₂
• 分子量: 283.347
• InChiKey: WQNHEWLWFDFOGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  86.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  二硫化碳 、 4-溴甲基-5H-呋喃-2-酮 、 4-氟苯胺 在 11H₂O*3Na⁽¹⁺⁾*O₄P^(3-) 作用下， 以 丙酮 为溶剂， 反应 0.5h， 以79%的产率得到1-(4-Fluorophenyl)-2-sulfanylidene-7-oxa-3-thia-1-azaspiro[4.4]nonan-8-one
  参考文献：
  名称：

  Synthesis of Various Substituted Spiro- and Bicyclethiazolidine-2-thiones by a Multicomponent Reaction and Biological Evaluation in vitro

  摘要：

  A series of novel spiro[4.4] and bicycle[3.3.0]-N-substituted thiazolidine-2-thiones were obtained by a multicomponent reaction under mild conditions. Each of the synthesized compounds was evaluated for their cytotoxic activity and antibacterial activity. Some of them exhibited significantly inhibited proliferation of human tumor cell lines and moderate inhibitory effect on fungi.

  DOI：

  10.3987/com-11-12147

文献信息

• Synthesis of Various Substituted Spiro- and Bicyclethiazolidine-2-thiones by a Multicomponent Reaction and Biological Evaluation in vitro
  作者：Hong-Min Liu、Xiao-Juan Wang、Hai-Wei Xu、Lin-Lin Guo、En Zhang、Guang-Wei Chen、Xiao Guo

  DOI：10.3987/com-11-12147

  日期：——

  A series of novel spiro[4.4] and bicycle[3.3.0]-N-substituted thiazolidine-2-thiones were obtained by a multicomponent reaction under mild conditions. Each of the synthesized compounds was evaluated for their cytotoxic activity and antibacterial activity. Some of them exhibited significantly inhibited proliferation of human tumor cell lines and moderate inhibitory effect on fungi.