3-(1,1-Dimethylethyl)-2,5-dimethyl-1H-pyrrole | 15345-59-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3-(1,1-Dimethylethyl)-2,5-dimethyl-1H-pyrrole
• 英文别名: 3-tert-butyl-2,5-dimethyl-1H-pyrrole
• CAS: 15345-59-2
• 化学式: C₁₀H₁₇N
• 分子量: 151.25
• InChiKey: XLMMXIRLHIENCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  0

文献信息

• Anti-Viral Compounds
  申请人：DeGoey David A.

  公开号：US20110207699A1

  公开（公告）日：2011-08-25

  Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

  本发明描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。本发明还涉及制造这种化合物的过程、包含这种化合物的组合物以及使用这种化合物治疗HCV感染的方法。
• 2,4,6,7-TETRASUBSTITUTED QUINOLINE COMPOUNDS AS INHIBITORS OF DNA METHYLTRANSFERASES
  申请人：FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA

  公开号：US20190127354A1

  公开（公告）日：2019-05-02

  It relates to the compounds of formula (I), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures of stereoisomers, wherein R is a radical selected from the group consisting of formula (A), formula (B), formula (C), formula (D), and formula (E), and R 1 , R 2 , and R 3 are as defined herein, which are inhibitors of one or more DNMTs selected from the group consisting of DNMT1, DNMT3A and DNMT3B. It also relates to pharmaceutical or veterinary compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of cancer, fibrosis and/or immunomodulation.