2-[(5R,3R)-5-(2,4-difluorophenyl)-tetrahydro-5-(1H-1,2,4-triazol-1-yl-methyl)-furan-3-yl-methyl]-4-[4-(2,2,3,3-tetrafluoropropoxy)-pheny]-2,4-dihydro-3(2H,4H)-1,2,4-triazolone. | 616897-35-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-[(5R,3R)-5-(2,4-difluorophenyl)-tetrahydro-5-(1H-1,2,4-triazol-1-yl-methyl)-furan-3-yl-methyl]-4-[4-(2,2,3,3-tetrafluoropropoxy)-pheny]-2,4-dihydro-3(2H,4H)-1,2,4-triazolone.
• 英文别名: 2-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methyl]-4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-1,2,4-triazol-3-one
• CAS: 616897-35-9
• 化学式: C₂₅H₂₂F₆N₆O₃
• 分子量: 568.478
• InChiKey: ZOFGYZMUJMSGDJ-GYCJOSAFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  85.1
• 氢给体数：
  0
• 氢受体数：
  12

文献信息

• Amine derivative
  申请人：Abe Hidenori

  公开号：US20050245571A1

  公开（公告）日：2005-11-03

  The present invention provide a compound of the formula: wherein X and X′ are the same or different and each represents a hydrogen atom, etc.; R 1 and R 2 are the same or different and each represents a hydrogen atom, etc.; R 3 represents a hydrocarbon group optionally having substituents, etc.; R 4 represents a hydrogen atom, etc.; Y and Ya are the same or different and each represents a bond or a spacer having a main chain of 1 to 8 atoms; Z and Za are the same or different and each represents a hydrogen atom, etc.; or a salt thereof or a prodrug thereof, having a somatostatin receptor binding inhibitory activity and is useful for preventing and/or treating diseases associated with somatostatin.

  本发明提供一种化合物，其式为：其中X和X′相同或不同，每个代表氢原子等；R1和R2相同或不同，每个代表氢原子等；R3表示一个烃基，可选地具有取代基等；R4表示氢原子等；Y和Ya相同或不同，每个代表键或具有1至8个原子的主链的间隔物；Z和Za相同或不同，每个代表氢原子等；或其盐或前药，具有生长抑素受体结合抑制活性，并用于预防和/或治疗与生长抑素相关的疾病。
• Derivatives of 2,2,4-trisubstituted tetrahydrofuran an antifungal agents
  申请人：Salman Mohammad

  公开号：US20050261330A1

  公开（公告）日：2005-11-24

  The present invention relates to derivatives of 2,2,4-trisubstituted tetrahydrofuran as potential antifungal agents. This invention also relates to pharmaceutical compositions containing the compounds of the present invention and their use in treating and/or preventing the fungal infections in mammals, preferably humans.

  本发明涉及作为潜在抗真菌剂的 2,2,4-三取代四氢呋喃的衍生物。本发明还涉及含有本发明化合物的药物组合物及其在治疗和/或预防哺乳动物（最好是人类）真菌感染中的用途。
• DERIVATIVES OF 2,2,4-TRISUBSTITUTED TETRAHYDROFURAN AS ANTIFUNGAL AGENTS
  申请人：RANBAXY LABORATORIES, LTD.

  公开号：EP1497298A1

  公开（公告）日：2005-01-19
• [EN] DERIVATIVES OF 2,2,4-TRISUBSTITUTED TETRAHYDROFURAN AS ANTIFUNGAL AGENTS<br/>[FR] DERIVES DE TETRAHYDROFURANE TRISUBSTITUES 2,2,4 UTILISES COMME AGENTS ANTIFONGIQUES
  申请人：RANBAXY LAB LTD

  公开号：WO2003087106A1

  公开（公告）日：2003-10-23

  The present invention relates to derivatives of 2,2,4-trisubstituted tetrahydrofuran as potential antifungal agents. This invention also relates to pharmaceutical compositions containing the compounds of the present invention and their use in treating and/or preventing the fungal infections in mammals, preferably humans.