arginino-succinic acid | 21020-81-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: arginino-succinic acid
• 英文别名: N-{(1S)-1-Carboxy-4-[(diaminomethylidene)amino]butyl}aspartic acid；2-[[(1S)-1-carboxy-4-(diaminomethylideneamino)butyl]amino]butanedioic acid
• CAS: 21020-81-5
• 化学式: C₁₀H₁₈N₄O₆
• 分子量: 290.276
• InChiKey: ZAJYCVKCRQCISF-ZBHICJROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.6
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  188
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  马来酸酐 、 L-精氨酸 在 水 、 sodium hydroxide 作用下， 生成 arginino-succinic acid
  参考文献：
  名称：

  アルギニン誘導体を含有する化粧料組成物

  摘要：

  【问题】提供一种含有精氨酸衍生物的化妆品组合物，通过添加到头发化妆品中，可以增加头发的体积，具有优良的保湿性和改善触感的效果，从而提高其产品价值。 【解决方案】 化妆品组合物包含式（1）所示的精氨酸衍生物。 [其中，S是0或1的整数；R1是H或-CH2COOH；p是0-3的整数；X是亲水基；式（2）所示的含有Nα氮的取代基的无机价值为300以上] [符号在公式（1）中等效] 【选择图】无

  公开号：

  JP2016064994A

文献信息

• Polyvalent multimeric composition containing active polypeptides, pharmaceutical compositions and methods of using the same
  申请人：Kallenbach Neville

  公开号：US20070053934A1

  公开（公告）日：2007-03-08

  The invention is directed to compositions comprising polyvalent complexes containing a biocompatible polymer backbone to which is attached a plurality of monomeric anti-microbial peptides and to methods for using such complexes to stabilize anti-microbial peptides for treating or preventing a disease or condition resulting from infection with a microbe. Multivalent derivatives of existing antimicrobial peptides in which several peptides are covalently linked have been investigated. The resulting construct may contain up to 30 or more units, and exhibits a significant enhancement of anti-microbial effect relative to the free peptides: on the order of a ten fold improvement in effectiveness, suggesting that higher multimerization can indeed lead to more effective agents. The invention is also directed to the use of such complexes for delivery of anti-viral peptides, in particular, peptides and peptide fragments obtained from salivary agglutinin protein (gp-340) for use in treating or preventing infection with HIV.

  该发明涉及包含聚价复合物的组合物，其中聚价复合物含有生物相容性聚合物骨架，该骨架连接有多种单体抗微生物肽，并且涉及使用这种复合物来稳定抗微生物肽，以治疗或预防由微生物感染引起的疾病或状况的方法。已经研究了现有抗微生物肽的多价衍生物，其中几种肽被共价连接。所得的构建物可能包含多达30个或更多单元，并且相对于自由肽，其抗微生物效果显著增强：效果提高了大约十倍，表明更高的多聚化确实可以导致更有效的药物。该发明还涉及使用这种复合物用于传递抗病毒肽，特别是用于治疗或预防HIV感染的唾液凝集素蛋白（gp-340）获得的肽和肽片段。
• Compositions and methods for modeling saccharomyces cerevisiae metabolism
  申请人：The Regents of The University of California

  公开号：EP2463654A1

  公开（公告）日：2012-06-13

  The invention provides an in silica model for determining a S. cerevisiae physiological function. The model includes a data structure relating a plurality of S. cerevisiae reactants to a plurality of S. cerevisiae reactions, a constraint set for the plurality of S. cerevisiae reactions, and commands for determining a distribution of flux through the reactions that is predictive of a S. cerevisiae physiological function. A model of the invention can further include a gene database containing information characterizing the associated gene or genes. The invention further provides methods for making an in silica S. cerevisiae model and methods for determining a S. cerevisiae physiological function using a model of the invention. The invention provides an in silica model for determining a S. cerevisiae physiological function. The model includes a data structure relating a plurality of S. cerevisiae reactants to a plurality of S. cerevisiae reactions, a constraint set for the plurality of S. cerevisiae reactions, and commands for determining a distribution of flux through the reactions that is predictive of a S. cerevisiae physiological function. A model of the invention can further include a gene database containing information characterizing the associated gene or genes. The invention further provides methods for making an in silica S. cerevisiae model and methods for determining a S. cerevisiae physiological function using a model of the invention.

  本发明提供了一种用于确定酿酒葡萄孢菌生理功能的硅胶模型。该模型包括一个将多个酿酒葡萄孢反应物与多个酿酒葡萄孢反应相关联的数据结构、多个酿酒葡萄孢反应的约束集，以及用于确定通过反应的通量分布的指令，该通量分布可预测酿酒葡萄孢的生理功能。本发明的模型可进一步包括一个基因数据库，其中包含表征相关基因的信息。本发明进一步提供了硅胶中酿酒葡萄孢模型的制作方法和使用本发明模型确定酿酒葡萄孢生理功能的方法。本发明提供了一种用于确定酿酒葡萄孢菌生理功能的硅胶模型。该模型包括将多个酿酒葡萄孢反应物与多个酿酒葡萄孢反应相关联的数据结构、多个酿酒葡萄孢反应的约束集，以及用于确定通过反应的通量分布的指令，该通量分布可预测酿酒葡萄孢的生理功能。本发明的模型可进一步包括一个基因数据库，其中包含表征相关基因的信息。本发明进一步提供了制作硅胶葡萄孢菌模型的方法和使用本发明模型确定葡萄孢菌生理功能的方法。
• Peptide treatment for inflammation and fibrosis
  申请人：The Regents of the University of California

  公开号：US10434134B2

  公开（公告）日：2019-10-08

  The invention is directed to peptides which inhibit phosphorylation of an amino phosphoacceptor domain of C/EBPβ and their use for treating inflammation and fibrosis.

  本发明涉及抑制 C/EBPβ 氨基磷酸化受体结构域磷酸化的多肽及其用于治疗炎症和纤维化的用途。
• Targeting GIV-GEF-GI signaling for treating diverse diseases
  申请人：The Regents of the University of California

  公开号：US10653749B2

  公开（公告）日：2020-05-19

  The invention provides cell-permeable Ga-Interacting Vesicle associated protein (GIV)-derived peptides and their use for treatment of diverse diseases. The invention further provides C-terminus of Ga-Interacting Vesicle associated protein (GIV-CT)-based peptides and GIV-CT encoding vectors and methods of use thereof, for successfully manipulating the diverse pathophysiologic processes in which GIV has been implicated. In one aspect, the invention provides cell-permeable peptides PTD-GIV-CT comprising (i) a peptide transduction domain (PTD) and (ii) a C-terminus of Ga-Interacting Vesicle associated protein (GIV-CT) or a mutant thereof. In one embodiment, said peptides are capable of activating Gi downstream of receptor tyrosine kinases (RTKs). The invention also provides pharmaceutical compositions comprising one or more of the peptides of the invention as well as vectors encoding such peptides.

  本发明提供了细胞渗透性Ga-Interacting囊泡相关蛋白（GIV）衍生的多肽及其用于治疗多种疾病的方法。本发明进一步提供了基于Ga-Interacting Vesicle associated protein (GIV-CT)的C-末端多肽和GIV-CT编码载体及其使用方法，用于成功地操纵GIV已被牵涉到的各种病理生理过程。在一个方面，本发明提供了细胞渗透性多肽 PTD-GIV-CT，其包含(i)多肽转导结构域（PTD）和(ii)Ga-Interacting Vesicle associated protein (GIV-CT)的C端或其突变体。在一个实施方案中，所述多肽能够激活受体酪氨酸激酶（RTK）下游的 Gi。本发明还提供了包含一种或多种本发明多肽的药物组合物以及编码此类多肽的载体。
• Glycosylated LPXTGases and uses thereof
  申请人：——

  公开号：US20040146984A1

  公开（公告）日：2004-07-29

  An endopeptidase is described which shows specificity for cleavage of a LPXTG (SEQ ID NO: 1) motif found in the cell membranes of gram positive bacteria, having an apparent molecular weight of 14,000 daltons, having a pH optimum of about 7.5 to 10, being salt sensitive, being heavily glycosylated, rich in alanine, lacking aromatic amino acids, having a K m of 0.26 mM and having a backbone comprised of about 30% unknown amino acids, and containing carbohydrates that are essential for its activity. Methods of use and pharmaceutical compositions of this inhibitor are described.

  描述了一种内肽酶，它对裂解革兰氏阳性细菌细胞膜上的 LPXTG（SEQ ID NO: 1）图案具有特异性，其表观分子量为 14,000 道尔顿，pH 值最适为 7.5 至 10，对盐敏感，糖基化严重，富含丙氨酸，缺乏芳香族氨基酸，K m 为 0.26 mM，骨架由大约 30% 的未知氨基酸组成，并含有其活性所必需的碳水化合物。本文介绍了这种抑制剂的使用方法和药物组合物。