2-Diphenylphosphinylthiophenol | 119327-20-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Diphenylphosphinylthiophenol
• 英文别名: 2-diphenylphosphorylbenzenethiol
• CAS: 119327-20-7
• 化学式: C₁₈H₁₅OPS
• 分子量: 310.356
• InChiKey: NQCMSUPYHOZTTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  18.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二甲基二氯化锡 、 2-Diphenylphosphinylthiophenol 在 NaOEt 作用下， 以 乙醇 为溶剂， 以82%的产率得到
  参考文献：
  名称：

  Synthesis and characterisation of phosphinothiolate tin(IV) complexes. Crystal structure of [SntBu2(OPPh2C6H4S)(OH2)]ClO4·H2O

  摘要：

  [SnR2Cl2] (R = Me, 'Bu) react with OPPh2C6H4SH in the presence of NaOEt affording mononuclear derivatives [SnR2(OPPh2C6H4S)(2)] (1, 2) with two units of the oxide of the thiophenylphosphine. The loss of one of such units is achieved by the reaction of 1 and 2 with HCF3SO3 or HClO4 giving rise to complexes with the formula [SnR2(OPPh2C6H4S)]A (A = CF3SO3, ClO4) (3a-b, 4a-b). The crystal structure of [Sn'Bu-2(OPPh2C6H4S)]ClO4 (4b) has been determined by X-ray diffraction. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0277-5387(01)00897-x
• 作为产物：
  描述：

  2-(二苯基膦基)苯硫酚 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 28.0h， 生成 2-Diphenylphosphinylthiophenol
  参考文献：
  名称：

  Staudinger Ligation:  A Peptide from a Thioester and Azide

  摘要：

  The technique of native chemical ligation enables the total chemical synthesis of proteins. This method is limited, however, by an absolute requirement for a cysteine residue at the ligation juncture. Here, this restriction is overcome with a new chemical ligation method in which a phosphinobenzenethiol is used to link a thioester and azide. The product is an amide with no residual atoms.

  DOI：

  10.1021/ol0060174

文献信息

• 2-Phosphino- and 2-phosphinylbenzenethiols: new ligand types
  作者：Eric Block、Gabriel Ofori-Okai、Jon Zubieta

  DOI：10.1021/ja00188a071

  日期：1989.3