1-(4-hydroxy-phenyl)-3-methylene-pyrrolidine-2,5-dione | 139114-33-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(4-hydroxy-phenyl)-3-methylene-pyrrolidine-2,5-dione
• 英文别名: 1-(4-Hydroxy-phenyl)-3-methylen-pyrrolidin-2,5-dion；1-(4-Hydroxyphenyl)-3-methylidenepyrrolidine-2,5-dione
• CAS: 139114-33-3
• 化学式: C₁₁H₉NO₃
• 分子量: 203.197
• InChiKey: VATANMDVMGIISU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(4-hydroxy-phenyl)-3-methylene-pyrrolidine-2,5-dione 、 5-(2-hydroxybenzylidene)-4-thioxo-2-thiazolidinone 在 溶剂黄146 、 对苯二酚 作用下， 反应 2.0h， 以42%的产率得到rel-(6′R,7′R)-7′-(2-hydroxyphenyl)-1-(4-hydroxyphenyl)-3′,7′-dihydro-2H,2′H,5H-spiro[pyrolidin-3,6′-thiopyrano[2,3-d]thiazol]-2,2′,5-trione
  参考文献：
  名称：

  Synthesis and antitrypanosomal activity of new 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles

  摘要：

  A series of novel 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles-based molecules have been synthesized and evaluated as potential antitrypanosomal agents. The most active analogue 3b inhibited Trypanosoma brucei brucei and Trypanosoma brucei gambiense with an IC50 of 0.26 and 0.42 mu M, respectively. They could be considered as potent hits for further antitrypanosomal drug discovery efforts. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.09.091
• 作为产物：
  描述：

  衣康酸酐 、 对氨基苯酚 生成 1-(4-hydroxy-phenyl)-3-methylene-pyrrolidine-2,5-dione
  参考文献：
  名称：

  Piutti, Gazzetta Chimica Italiana, 1906, vol. 36, p. II 365

  摘要：

  DOI：

文献信息

• Piutti, Gazzetta Chimica Italiana, 1910, vol. 40, p. I, 545
  作者：Piutti

  DOI：——

  日期：——
• Urban Environmental Justice Indices
  作者：John Harner、Kee Warner、John Pierce、Tom Huber

  DOI：10.1111/0033-0124.00333

  日期：2002.8.1

  Environmental justice is the principle that environmental costs and amenities ought to be equitably distributed within society. Due to the ethical. political, and public-health implications, and because many choices confront those researching environmental justice, standardized measures are needed to inform public dialogue and policy. We develop and test semen indices on three Colorado cities to measure the relationship between the distribution of environmental hazards and minority and poverty-stricken populations and recommend the Comparative Environmental Risk Index as a preliminary, standardized measure for comparing urban area. This index is particularly relevant to disadvantaged communities, regional planning organization, environmental-justice networks and scholars, and state and federal agencies.