ethyl 3-(3-fluorophenyl)-2-(4-methoxyphenylamino)propanoate | 1093847-25-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 3-(3-fluorophenyl)-2-(4-methoxyphenylamino)propanoate
• CAS: 1093847-25-6
• 化学式: C₁₈H₂₀FNO₃
• 分子量: 317.36
• InChiKey: QZRDXJGLSKFUQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.42
• 重原子数：
  23.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  47.56
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  乙醛酸乙酯 、 甲氧苯胺 、 3-氟溴苄 在 锌 作用下， 以 甲苯 、 乙腈 为溶剂， 反应 1.0h， 以67%的产率得到ethyl 3-(3-fluorophenyl)-2-(4-methoxyphenylamino)propanoate
  参考文献：
  名称：

  A Straightforward Three-Component Synthesis of α-Amino Esters Containing a Phenylalanine or a Phenylglycine Scaffold

  摘要：

  A range of alpha-amino esters has been synthesized in good to high yields using a straightforward three-component reaction among preformed or in situ generated aromatic or benzylic organozinc reagents, primary or secondary amines, and ethyl glyoxylate. The procedure, which is characterized by its simplicity, allows the concise synthesis of esters bearing a phenylglycine or a phenylalanine scaffold.

  DOI：

  10.1021/jo1002328

文献信息

• A concise three-component synthesis of α-amino esters derived from phenylglycine and phenylalanine
  作者：Caroline Haurena、Stéphane Sengmany、Paul Huguen、Erwan Le Gall、Thierry Martens、Michel Troupel

  DOI：10.1016/j.tetlet.2008.09.137

  日期：2008.12

  alpha-Amino esters have been synthesized using a straightforward three-component reaction among preformed or in situ-generated aromatic or benzylic organozinc reagents, primary or secondary amines and ethyl glyoxylate. The procedure, which is characterized by its simplicity, allows the concise synthesis of phenylglycine and phenylalanine derivatives, (C) 2008 Elsevier Ltd. All rights reserved.