H-Arg-4MβNA（盐酸盐） | 60285-94-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: H-Arg-4MβNA（盐酸盐）
• 英文名称: H-Arg-4MbetaNA
• 英文别名: (2S)-2-amino-5-(diaminomethylideneamino)-N-(4-methoxynaphthalen-2-yl)pentanamide
• CAS: 60285-94-1
• 化学式: C₁₇H₂₃N₅O₂
• 分子量: 329.4
• InChiKey: XVHWVDFGKDNOBO-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  4

制备方法与用途

生物活性

H-Arg-4MβNA 是 cathepsin H 的底物，可用于凝胶电泳中检测酶活性。

文献信息

• Therapeutic and diagnostic ligand systems comprising transport molecule binding properties and medicaments containing the same
  申请人：——

  公开号：US20030185793A1

  公开（公告）日：2003-10-02

  The invention relates to transport molecule binding ligand compounds which comprise a therapeutically and/or diagnostically active substance and a carrier molecule-affine substance with a high association constant to the carrier molecule. The invention also relates to medicaments containing these ligand compounds and to diagnostic kits.

  这项发明涉及与载体分子结合的配体化合物，其包括具有治疗和/或诊断活性物质以及与载体分子具有高结合常数的载体分子亲和物质。该发明还涉及含有这些配体化合物的药物和诊断试剂盒。
• DEVICE AND METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO-OR NANOEMULSIFICATION
  申请人：Dietz Ulrich

  公开号：US20130090488A1

  公开（公告）日：2013-04-11

  The present invention is directed to solubilizing compounds, a device and a method for solubilizing and removing carboxylic acids and especially fatty acids from oils, fats, aqueous emulsion, aqueous media and organic solutions. Devices utilizing the inventive method shall be used for separating carboxylic acids from oils, fats, aqueous emulsion, lipophilic media or organic solutions, respectively by preparing an aqueous micro- or nanoemulsion of the carboxylic acids especially the fatty acids and the solubilizing compound which contains at least one amidino and/or gianidino group. Solubilization effects of solubilizing compounds combined with the inventive use of separation methods for carboxylic acids can be used to treat persons in need of removal of fatty acids or analyze carboxylic acids from blood or process other solutions in food, pharmacy, chemistry, bio fuel industry or other industrial processings.

  本发明涉及溶解化合物、用于从油、脂肪、水乳液、水介质和有机溶液中溶解和去除羧酸，特别是脂肪酸的装置和方法。采用本发明方法的装置将用于通过制备羧酸特别是脂肪酸和含有至少一种氨基甲酰基和/或肼基团的溶解化合物的水微观或纳米乳液，分离油、脂肪、水乳液、亲脂性介质或有机溶液中的羧酸。溶解化合物的溶解效果与本发明所述的羧酸分离方法相结合，可用于治疗需要去除脂肪酸或从血液中分析羧酸或处理食品、药品、化学、生物燃料工业或其他工业加工过程中的其他溶液的人员。
• Laxative preparation containing l-Arginine
  申请人：Norgine BV

  公开号：EP2022494A2

  公开（公告）日：2009-02-11

  The invention relates to L-arginine, a derivative thereof or a pharmaceutically acceptable salt thereof for use as a laxative, for treatment of constipation and for clearing the rectum and/or the colon of a mammal. Compositions suitable for topical administration to an area of the gastrointestinal tract are provided. Orally administered preparations comprising for example an enteric coating that dissolves at a desired location in the gastrointestinal tract; a controlled release formulation; a sustained release formulation; a targeted drug delivery system; or a combination thereof are also provided.

  本发明涉及用作泻药、治疗便秘和清除哺乳动物直肠和/或结肠的 L-精氨酸、其衍生物或其药学上可接受的盐。提供了适用于胃肠道局部给药的制剂。此外，还提供了口服制剂，例如包括可在胃肠道所需位置溶解的肠溶衣；控释制剂；缓释制剂；靶向给药系统；或其组合。
• DEVICE FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO- OR NANOEMULSIFICATION
  申请人：Dietz, Ulrich

  公开号：EP3042718A1

  公开（公告）日：2016-07-13

  The present invention is directed to a device for solubilizing and removing carboxylic acids and especially fatty acids from oils, fats, aqueous emulsion, aqueous media and organic solutions. Devices utilizing the herein disclosed method shall be used for separating carboxylic acids from oils, fats, aqueous emulsion, lipophilic media or organic solutions, respectively by preparing an aqueous micro- or nanoemulsion of the carboxylic acids especially the fatty acids and the solubilizing compound which contains at least one amidino and/or gianidino group. Solubilization effects of solubilizing compounds combined with the use of the separation methods for carboxylic acids as discloses herein can be used to treat persons in need of removal of fatty acids or analyze carboxylic acids from blood or process other solutions in food, pharmacy, chemistry, bio fuel industry or other industrial processings.

  本发明涉及一种从油、脂肪、水乳液、水介质和有机溶液中增溶和去除羧酸，特别是脂肪酸的装置。通过制备羧酸（尤其是脂肪酸）和至少含有一个脒基和/或胍基的增溶化合物的水性微乳液或纳米乳液，利用本文公开的方法制备的设备可分别用于从油、脂肪、水性乳液、亲油介质或有机溶液中分离羧酸。增溶化合物的增溶作用与本文公开的羧酸分离方法相结合，可用于治疗需要从血液中去除脂肪酸或分析羧酸的人，或处理食品、制药、化学、生物燃料工业或其他工业加工中的其他溶液。
• TUMOR PROTEASE ACTIVATED PRODRUGS OF PHOSPHORAMIDE MUSTARD ANALOGS
  申请人：Drug Innovation & Design, Inc.

  公开号：EP0821689A1

  公开（公告）日：1998-02-04