4-(1,1-二甲基-丁基)-苯胺 | 114833-71-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(1,1-二甲基-丁基)-苯胺
• 英文名称: 4-(1,1-dimethyl-butyl)-aniline
• 英文别名: 4-(1,1-Dimethyl-butyl)-anilin；1-amino-4-(1,1-dimethylbutyl)benzene；4-(2-Methylpentan-2-yl)aniline
• CAS: 114833-71-5
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: RDTRZAAYUDTACI-UHFFFAOYSA-N

物化性质

• 沸点：
  107-109 °C(Press: 3 Torr)
• 密度：
  0.926±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(1,1-二甲基-丁基)-苯胺 在 吡啶 、 sodium hydroxide 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 2-Cyano-N-4-(1,1-dimethylbutyl)phenyl-3-hydroxybut-2-enamide
  参考文献：
  名称：

  Axton, Christopher A.; Billingham, Michael E. J.; Bishop, Paul M., Journal of the Chemical Society. Perkin transactions I, 1992, # 17, p. 2203 - 2214

  摘要：

  DOI：
• 作为产物：
  描述：

  (1,1-二甲基丁基)苯 在 盐酸 、 tin 、 硝酸 作用下， 生成 4-(1,1-二甲基-丁基)-苯胺
  参考文献：
  名称：

  Condensation of Aliphatic Alcohols with Aromatic Compounds in the Presence of Aluminum Chloride. I¹

  摘要：

  DOI：

  10.1021/ja01294a016

文献信息

• Revision of species of the “<i>Oligia</i>” <i>semicana</i> group (Lepidoptera: Noctuidae) with descriptions of a new genus and 12 new species
  作者：James T. Troubridge、J. Donald Lafontaine

  DOI：10.4039/ent134157-2

  日期：2002.4

  The name Neoligiagen.nov. is proposed for the “Oligia” semicana (Walker) species group in North America and 12 species, N. rubirena sp.nov., N. pagosa sp.nov., N. hardwicki sp.nov., N. inermis sp.nov., N. invenusta sp.nov., N. albirena sp.nov., N. lancea sp.nov., N. elephas sp.nov., N. lillooet sp.nov., N. surdirena sp.nov., N. canadensis sp.nov., and N. atlantica sp.nov. are described. Hadenella laevigata Smith is synonymized (synonymy restored) under Hadena tonsa Grote and Hadena hausta Grote is synonymized (synonymy restored) under Miana semicana Walker. Adults of all species are illustrated as well as male and female genitalia, where known.

  AbstractThe name Neoligiagen.nov. is proposed for the "Oligia" semicana (Walker) species group in North America and 12 species, N. rubirena sp.nov., N. pagosa sp.nov., N. hardwicki sp.nov、N. inermis sp.nov.、N. invenusta sp.nov.、N. albirena sp.nov.、N. lancea sp.nov.、N. elephas sp.nov.、N. lillooet sp.nov.、N. surdirena sp.nov.、N. canadensis sp.nov.和 N. atlantica sp.nov.等 12 个种。Hadenella laevigata Smith 与 Hadena tonsa Grote 同源（同义恢复），Hadena hausta Grote 与 Miana semicana Walker 同源（同义恢复）。所有物种的成体以及已知的雄性和雌性生殖器均附有插图。
• N-phenyl amide compounds
  申请人：Lilly Industries Limited

  公开号：US04892963A1

  公开（公告）日：1990-01-09

  Compounds of the following formula have pharmaceutical properties: ##STR1## in which X is R.sup.1 (HO)C.dbd.C(CN)--, R.sup.1 (CO)--CH(CN)-- or ##STR2## R.sup.1 and R.sup.2 are each hydrogen or C.sub.1-6 alkyl, R.sup.3, R.sup.4 and R.sup.5 are each hydrogen, hydroxy, halogen, nitro, cyano, carboxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, halo-substituted C.sub.1-4 alkyl, halo-substituted C.sub.1-4 alkoxy, halo-substituted C.sub.1-4 alkylthio, C.sub.2-5 alkoxycarbonyl, optionally substituted phenyl, optionally substituted phenoxy, R'R"N- where R' and R" are each hydrogen or C.sub.1-4 alkyl R'"CONH-- where R'" is C.sub.1-4 alkyl, R.sup.6, R.sup.7 and R.sup.8 are each C.sub.1-6 alkyl, halo-substituted C.sub.1-6 alkyl or optionally substituted phenyl, or R.sup.6 and R.sup.7, together with the carbon atom to which they are attached, form a cycloalkyl group containing 3 to 7 carbon atoms, or R.sup.6, R.sup.7 and R.sup.8 together with the carbon atom to which they are attached, form a bicycloalkyl group containing 4 to 9 carbon atoms; and salts thereof.

  以下化合物具有药用性质的公式：##STR1## 其中X为R.sup.1(HO)C.dbd.C(CN)--，R.sup.1(CO)--CH(CN)--或##STR2## R.sup.1和R.sup.2分别为氢或C.sub.1-6烷基，R.sup.3、R.sup.4和R.sup.5分别为氢、羟基、卤素、硝基、氰基、羧基、C.sub.1-4烷基、C.sub.1-4烷氧基、C.sub.1-4烷硫基、卤素取代的C.sub.1-4烷基、卤素取代的C.sub.1-4烷氧基、卤素取代的C.sub.1-4烷硫基、C.sub.2-5烷氧羰基、可选择取代的苯基、可选择取代的苯氧基、R'R"N-其中R'和R"分别为氢或C.sub.1-4烷基，R'"CONH--其中R'"为C.sub.1-4烷基，R.sup.6、R.sup.7和R.sup.8分别为C.sub.1-6烷基、卤素取代的C.sub.1-6烷基或可选择取代的苯基，或者R.sup.6和R.sup.7与它们连接的碳原子一起形成含有3到7个碳原子的环烷基，或者R.sup.6、R.sup.7和R.sup.8与连接它们的碳原子一起形成含有4到9个碳原子的双环烷基；以及其盐。
• Penicinotam derivative, preparation method and use thereof
  申请人：OCEAN UNIVERSITY OF CHINA

  公开号：US11040028B2

  公开（公告）日：2021-06-22

  Provided are penicinotam derivatives, a tautomer, a stereoisomer, a racemate, a nonequal mixture of enantiomers, a geometric isomer, a solvate, a pharmaceutically acceptable salt or a prodrug thereof, and a pharmaceutical composition comprising the derivatives. Also provided herein is use of the derivatives and the pharmaceutical compositions in treating diseases caused by inflammation, immune system disorders.

  本文提供了青霉胺衍生物、同分异构体、立体异构体、外消旋体、对映体的非等价混合物、几何异构体、溶液、其药学上可接受的盐或原药，以及包含这些衍生物的药物组合物。本文还提供了这些衍生物和药物组合物在治疗炎症引起的疾病、免疫系统疾病中的用途。
• N-Phenyl butenamides with pharmaceutical properties
  申请人：LILLY INDUSTRIES LIMITED

  公开号：EP0257882B1

  公开（公告）日：1991-07-24
• US4892963A
  申请人：——

  公开号：US4892963A

  公开（公告）日：1990-01-09