2-methyl-2-[methyl(oxan-4-ylmethyl)amino]-N-[3-[2-methyl-1-(oxan-2-yloxy)propan-2-yl]-1,2-oxazol-5-yl]propanamide | 1259020-82-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-methyl-2-[methyl(oxan-4-ylmethyl)amino]-N-[3-[2-methyl-1-(oxan-2-yloxy)propan-2-yl]-1,2-oxazol-5-yl]propanamide
• CAS: 1259020-82-0
• 化学式: C₂₃H₃₉N₃O₅
• 分子量: 437.58
• InChiKey: KOTLYISTEHMCBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  86.1
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Compounds which selectively modulate the CB2 receptor
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2716635B1

  公开（公告）日：2017-02-01
• Compounds Which Selectively Modulate The CB2 Receptor
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20130030022A1

  公开（公告）日：2013-01-31

  Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
• US8735430B2
  申请人：——

  公开号：US8735430B2

  公开（公告）日：2014-05-27
• [EN] COMPOUNDS WHICH SELECTIVELY MODULATE THE CB2 RECEPTOR<br/>[FR] COMPOSÉS QUI MODULENT SÉLECTIVEMENT LE RÉCEPTEUR CB2
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2010147792A2

  公开（公告）日：2010-12-23

  Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.