14-Hexyloxytetradec-5(Z)-enoic acid | 1020733-51-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 14-Hexyloxytetradec-5(Z)-enoic acid
• 英文别名: (Z)-14-(hexyloxy)tetradec-5-enoate；(Z)-14-hexoxytetradec-5-enoic acid
• CAS: 1020733-51-0
• 化学式: C₂₀H₃₈O₃
• 分子量: 326.52
• InChiKey: POXATXOOPIJVHS-NTMALXAHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  23
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Modulators of Pulmonary Hypertension
  申请人：Falck R. John

  公开号：US20080095711A1

  公开（公告）日：2008-04-24

  Compounds, compositions, and methods for inhibiting pulmonary hypertension are disclosed. The invention is particularly directed to the use of agents that specifically inhibit the activity of certain endogenously produced epoxyeicosatrienoic acids that promote vasoconstriction of pulmonary arteries. These agents are particularly useful for inhibiting hypoxia-induced pulmonary hypertension. The invention further discloses additional compounds, compositions and methods for increasing pulmonary hypertension.

  揭示了用于抑制肺动脉高压的化合物、组合物和方法。该发明特别指向了使用特定抑制某些内源性产生的促进肺动脉血管收缩的环氧三烯酸的活性的药剂。这些药剂特别适用于抑制缺氧诱导的肺动脉高压。该发明还揭示了用于增加肺动脉高压的额外化合物、组合物和方法。
• Compositions and Methods for the Treatment of Renal and Cardiovascular Disease
  申请人：Imig John D.

  公开号：US20080146663A1

  公开（公告）日：2008-06-19

  Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative compounds. The present invention further provides methods for the use of such compositions for the treatment of renal or cardiovascular disease and/or related conditions.

  本发明提供了模拟环氧代谢产物的11-壬氧基-十一烯酸的衍生物化合物。还提供了包含治疗有效量的衍生物化合物的组合物。本发明还提供了使用这些组合物治疗肾脏或心血管疾病和/或相关疾病的方法。
• US7550617B2
  申请人：——

  公开号：US7550617B2

  公开（公告）日：2009-06-23
• US7732470B2
  申请人：——

  公开号：US7732470B2

  公开（公告）日：2010-06-08