N,N,N-Trimethyl-m-anisidiniumion | 22237-93-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N,N,N-Trimethyl-m-anisidiniumion
• 英文别名: 3-Trimethylammoniumphenylmethylether；(3-Methoxy-phenyl)-trimethyl-ammonium；(3-methoxyphenyl)-trimethylazanium
• CAS: 22237-93-0
• 化学式: C₁₀H₁₆NO
• 分子量: 166.243
• InChiKey: WHPHDAQHXCWDGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC DISEASES
  申请人：CELLIXBIO PRIVATE LIMITED

  公开号：US20150291590A1

  公开（公告）日：2015-10-15

  The invention relates to the compounds of formula I, formula II and formula III or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II or formula III; and methods for treating or preventing metabolic diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of phenylketonuria, cardiovascular disease, autism, ADHD, hypertension, endothelial dysfunction and chronic kidney disease.

  该发明涉及公式I、公式II和公式III的化合物或其药用可接受的盐，以及其多晶型、溶剂合物、对映体、立体异构体和水合物。包括公式I、公式II或公式III化合物的有效量的药物组合物；以及用于治疗或预防代谢性疾病的方法可以制备成口服、颊内、直肠、局部、经皮、经粘膜、静脉、肠道、糖浆或注射剂。这些组合物可用于治疗苯丙酮尿症、心血管疾病、自闭症、注意力缺陷多动障碍、高血压、内皮功能障碍和慢性肾脏疾病。
• COMPOSITIONS AND METHODS FOR THE TREATMENT ANGINA AND CARDIOVASCULAR CONDITIONS
  申请人：Cellixbio Private Limited

  公开号：US20150148352A1

  公开（公告）日：2015-05-28

  The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of angina and cardiovascular conditions may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of chronic aneurysm, angina, atherosclerosis, cerebrovascular accident (stroke), cerebrovascular disease, congestive heart failure, coronary artery disease, myocardial infarction (heart attack), peripheral vascular disease, aortic dissection, aortic stenosis, arrhythmia (irregular heartbeat), atrial fibrillation, cardiomyopathy, chest pain, claudication, congenital heart disease.

  本发明涉及公式I化合物或其药学上可接受的盐，以及其多晶形、溶剂化合物、对映体、立体异构体和水合物。该药物组合物包括有效量的公式I化合物，并可制备用于口服、颊下、直肠、局部、经皮、经黏膜、静脉、肌肉注射、糖浆或注射的药物组合物，用于治疗心绞痛和心血管疾病的方法。这些组合物可用于治疗慢性动脉瘤、心绞痛、动脉粥样硬化、脑血管意外（中风）、脑血管疾病、充血性心力衰竭、冠状动脉疾病、心肌梗死（心脏病发作）、周围血管疾病、主动脉夹层、主动脉瓣狭窄、心律失常（心跳不规则）、心房颤动、心肌病、胸痛、跛行、先天性心脏病。
• PHTHALOCYANINE DERIVATIVE CONSISTING OF A MIXTURE OF 4 ISOMERS
  申请人：Roncucci Gabrio

  公开号：US20120135972A1

  公开（公告）日：2012-05-31

  There is described a phthalocyanine derivative of formula (I) consisting of 4 isomers wherein the relative isomer B content is less than or equal to 1% by weight.
• US9187427B2
  申请人：——

  公开号：US9187427B2

  公开（公告）日：2015-11-17