(3S)-3-Aminoheptanamide | 187948-34-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S)-3-Aminoheptanamide
• CAS: 187948-34-1
• 化学式: C₇H₁₆N₂O
• 分子量: 144.217
• InChiKey: RNCIZGLPDLNYDK-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  69.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] ENANTIO- AND STEREO-SPECIFIC SYNTHESES OF ß-AMINO-a- HYDROXY AMIDES<br/>[FR] SYNTHÈSES ÉNANTIO- ET STÉRÉOSPÉCIFIQUES DE ?-AMINO-?-HYDROXYAMIDES
  申请人：SCHERING CORP

  公开号：WO2011014494A1

  公开（公告）日：2011-02-03

  Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.

  用于制备化合物I的有用过程：公式（I）。用于制备化合物I的中间体，以及用于制备这些中间体的过程被披露。
• ESTERS AND AMIDES AS PLA2 INHIBITORS
  申请人：——

  公开号：US20020019416A1

  公开（公告）日：2002-02-14

  1 The present invention relates to a novel fatty acid derivative of formula (I), wherein R 1 is acyl group; R 2 is acyl(lower)alkyl; R 3 is hydrogen, aryl(lower)alkyl, etc.; R 4 is acyl(lower)alkyl; and X is —O—, —NH— or formula (II) [wherein R 5 is lower alkyl, etc.]; and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.

  本发明涉及一种新颖的脂肪酸衍生物，其化学式为（I），其中R1是酰基；R2是酰基（较低）烷基；R3是氢，芳基（较低）烷基等；R4是酰基（较低）烷基；X为—O—，—NH—或化学式（II）[其中R5为较低烷基等]；及其药学上可接受的盐，可用作药物；制备所述脂肪酸衍生物或其盐的方法；包含所述脂肪酸衍生物或其药学上可接受的盐的药物组合物等。
• Esters and amides as PLA2 inhibitors
  申请人：——

  公开号：US20040063959A1

  公开（公告）日：2004-04-01

  The present invention relates to a novel fatty acid derivative of the following formula: 1 wherein R 1 is acyl group; R 2 is acyl(lower)alkyl; R 3 is hydrogen, aryl(lower)alkyl, etc; R 4 is acyl(lower)alkyl; and X is —O—, —NH— or 2 [wherein R 5 is lower alkyl, etc]; and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.

  本发明涉及以下式子的新型脂肪酸衍生物：1其中R1是酰基；R2是酰基（较低）烷基；R3是氢、芳基（较低）烷基等；R4是酰基（较低）烷基；X是—O—、—NH—或2[其中R5是较低烷基等]；以及其药学上可接受的盐，其作为药物具有用途；制备该脂肪酸衍生物或其盐的方法；包含该脂肪酸衍生物或其药学上可接受的盐的制药组合物等。
• CAPREOMYCIN DERIVATIVES AND THEIR USE AS ANTIBACTERIALS
  申请人：Lyssikatos Joseph P.

  公开号：US20090203585A1

  公开（公告）日：2009-08-13

  The present invention relates to phenylurea derivatives of capreomycin I, IIB, IIA, or IB, and metabolites and pharmaceutically acceptable salts and solvates thereof. The compounds of the present invention are useful as antibacterial agents for treating bacterial infections and for treating disorders caused by bacterial infections. The present invention also relates to pharmaceutical compositions containing such compounds and to methods of treating bacterial infections by administering such compounds. The present invention also relates to methods of preparing such compounds.

  本发明涉及卡普雷霉素I、IIB、IIA或IB的苯基脲衍生物，以及其代谢产物和药学上可接受的盐和溶剂。本发明的化合物可用作治疗细菌感染和由细菌感染引起的疾病的抗菌剂。本发明还涉及含有这种化合物的制药组合物以及通过给予这种化合物来治疗细菌感染的方法。本发明还涉及制备这种化合物的方法。
• Epoxycarboxylic acid amides, azides and amino alcohols and processes for preparation of alpha-keto amides by using them
  申请人：SEIKAGAKU CORPORATION

  公开号：EP2289887A2

  公开（公告）日：2011-03-02

  The present invention is to provide manufacturing intermediates which can be led to useful α-ketoamide compounds having protease-inhibiting activity extremely economically and stereoselectively, and to provide azide compounds represented by the following formula: wherein R1 and R2 each represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; and processes for preparing α-keto amide compound using the same.

  本发明旨在提供可极其经济地、立体选择性地制备出具有蛋白酶抑制活性的有用 α-酮酰胺化合物的中间体，并提供下式所代表的叠氮化合物： 其中 R1 和 R2 分别代表烷基、烯基、芳香烃基或杂环基；以及使用上述化合物制备 α-酮酰胺化合物的工艺。