4-Methylamino-2-methylbuttersaeure | 79133-37-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-Methylamino-2-methylbuttersaeure
• 英文别名: 2-Methyl-4-methylamino-buttersaeure；2-Methyl-4-(methylamino)butanoic acid
• CAS: 79133-37-2
• 化学式: C₆H₁₃NO₂
• mdl: MFCD19218455
• 分子量: 131.175
• InChiKey: WOHRGBATUNFINP-UHFFFAOYSA-N

物化性质

• 沸点：
  238.2±23.0 °C(Predicted)
• 密度：
  0.998±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• 7-hydroxycoumarin-based cell-tracking reagents
  申请人：LIFE TECHNOLOGIES CORPORATION

  公开号：US11175204B1

  公开（公告）日：2021-11-16

  Described herein are compounds, methods, and kits for long-term tracking of cell proliferation, differentiation, and/or function. The compounds of the present invention are novel cell-tracking reagents, efficiently excitable with a 405-nm violet laser, that provide bright fluorescence intensity, uniform cell staining, and good retention within cells as well as low toxicity toward cells.

  本文描述的是用于长期跟踪细胞增殖、分化和/或功能的化合物、方法和试剂盒。本发明的化合物是一种新型细胞追踪试剂，可使用 405 纳米紫激光高效激发，具有荧光强度高、细胞染色均匀、在细胞内保留性好以及对细胞毒性低等特点。
• [EN] ANTIBODIES TO PMEL17 AND CONJUGATES THEREOF<br/>[FR] ANTICORPS DIRIGÉS CONTRE PMEL17 ET CONJUGUÉS DE CES DERNIERS
  申请人：NOVARTIS AG

  公开号：WO2020128612A2

  公开（公告）日：2020-06-25

  This application discloses anti-PMEL17 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.