N-(2-aminophenyl)-4-fluoro-2,3-dihydro-1H-indene-2-carboxamide | 1404560-27-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: N-(2-aminophenyl)-4-fluoro-2,3-dihydro-1H-indene-2-carboxamide
• CAS: 1404560-27-5
• 化学式: C₁₆H₁₅FN₂O
• 分子量: 270.306
• InChiKey: AQNRRFBEOIEBOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• COMBINATION OF A SELECTIVE HISTONE DEACETYLASE 3 (HDAC3) INHIBITOR AND AN IMMUNOTHERAPY AGENT FOR THE TREATMENT OF CANCER
  申请人：KDAc Therapeutics, Inc.

  公开号：US20190216754A1

  公开（公告）日：2019-07-18

  Aspects of the disclosure relate to compositions, kits, and methods for the treatment of cancer that utilize a selective histonc deacetylase 3 (HDAC3) inhibitor. In some aspects, the compositions, kits, and methods relate to use of a selective HDAC3 inhibitor in combination with an immunotherapy agent (e.g., an immune checkpoint inhibitor).

  披露的方面涉及使用选择性组蛋白去乙酰化酶3（HDAC3）抑制剂进行癌症治疗的组合物、试剂盒和方法。在某些方面，这些组合物、试剂盒和方法涉及使用选择性HDAC3抑制剂与免疫治疗药物（例如免疫检查点抑制剂）的结合。
• Inhibitors of Histone Deacetylase
  申请人：The Broad Institute, Inc.

  公开号：US20140080800A1

  公开（公告）日：2014-03-20

  The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R 2a , R 2b , R 2c , R 5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.

  本发明涉及式（I）的化合物：或其药学上可接受的盐、水合物、溶剂合物或前药，其中U、J、V、X、R2a、R2b、R2c、R5和t如本文所述。本发明通常涉及组织脱乙酰化酶抑制剂及其制备和使用方法。这些化合物有助于促进认知功能和增强学习和记忆形成。此外，这些化合物对于治疗、缓解和/或预防各种疾病有用，包括但不限于神经系统疾病、记忆和认知功能障碍、消退学习障碍、真菌病和感染、炎症性疾病、血液病和动物的肿瘤疾病。
• INHIBITORS OF HISTONE DEACETYLASE
  申请人：The Broad Institute, Inc.

  公开号：US20160251351A1

  公开（公告）日：2016-09-01

  The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R 1a , R 2b , R 2c , R 5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.

  本发明涉及化合物式(I)或其药学上可接受的盐、水合物、溶剂合物或前药，其中U、J、V、X、R1a、R2b、R2c、R5和t如本文所述。本发明通常涉及组织脱乙酰化酶抑制剂及其制备和使用方法。这些化合物有助于促进认知功能，增强学习和记忆形成。此外，这些化合物在治疗、缓解和/或预防各种疾病方面也很有用，包括例如神经系统疾病、记忆和认知功能障碍、消退学习障碍、真菌疾病和感染、炎症性疾病、血液疾病和动物的肿瘤性疾病。
• Inhibitors of histone deacetylase
  申请人：The Broad Institute, Inc.

  公开号：US10662199B2

  公开（公告）日：2020-05-26

  The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.

  本发明涉及式（I）化合物： 或其药学上可接受的盐、水合物、溶液或原药，其中 U、J、V、X、R2a、R2b、R2c、R5 和 t 如本文所述。本发明一般涉及组蛋白去乙酰化酶抑制剂及其制造和使用方法。这些化合物有助于促进认知功能，增强学习和记忆的形成。此外，这些化合物还可用于治疗、减轻和/或预防各种病症，包括例如人类和动物的神经系统疾病、记忆和认知功能障碍/损伤、绝迹学习障碍、真菌疾病和感染、炎症性疾病、血液病和肿瘤性疾病。
• US9365498B2
  申请人：——

  公开号：US9365498B2

  公开（公告）日：2016-06-14