1-Aminomethyl-2-(3,7-dimethyl-octyl)-cyclopropanecarboxylic acid | 724773-24-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-Aminomethyl-2-(3,7-dimethyl-octyl)-cyclopropanecarboxylic acid
• 英文别名: 1-(Aminomethyl)-2-(3,7-dimethyloctyl)cyclopropane-1-carboxylic acid
• CAS: 724773-24-4
• 化学式: C₁₅H₂₉NO₂
• 分子量: 255.401
• InChiKey: IQQFBINOBGINJB-UHFFFAOYSA-N

物化性质

• 沸点：
  370.3±15.0 °C(Predicted)
• 密度：
  0.985±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Cyclopropyl beta-amino acid derivatives
  申请人：——

  公开号：US20040147608A1

  公开（公告）日：2004-07-29

  This invention relates to novel cyclopropyl &bgr;-amino acids derivatives of the formula 1 wherein R 1 through R 4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl &bgr;-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (&agr;2&dgr; ligands). Such compounds have affinity for the &agr;2&dgr; subunit of a calcium channel.

  这项发明涉及公式1的新型环丙基β-氨基酸衍生物，其中R1至R4如规范中定义，含有它们的药物组合物以及它们用于治疗各种中枢神经系统和其他疾病的用途。本发明的环丙基β-氨基酸衍生物表现出作为α2δ配体（α2δ配体）的活性。这类化合物对钙通道的α2δ亚基具有亲和力。
• CYCLOPROPYL BETA-AMINO ACID DERIVATIVES
  申请人：Warner-Lambert Company LLC

  公开号：EP1592661A2

  公开（公告）日：2005-11-09
• US7030267B2
  申请人：——

  公开号：US7030267B2

  公开（公告）日：2006-04-18
• [EN] CYCLOPROPYL BETA-AMINO ACID DERIVATIVES<br/>[FR] DERIVES D'ACIDES BETA-AMINES DE CYCLOPROPYLE
  申请人：WARNER LAMBERT CO

  公开号：WO2004065361A2

  公开（公告）日：2004-08-05

  This invention relates to novel cyclopropyl β-amino acids derivatives of the formula (I) wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl β-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (α2δ ligands). Such compounds have affinity for the α2δ subunit of a calcium channel.