Δ^10,13-Docosadiensaeure | 104093-15-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Δ^10,13-Docosadiensaeure
• 英文别名: docosa-11,14-dienoic acid；Docosa-11,14-diensaeure；(11E,14E)-docosa-11,14-dienoic acid
• CAS: 104093-15-4
• 化学式: C₂₂H₄₀O₂
• 分子量: 336.558
• InChiKey: GGIGNDWYMFQYKS-MVKOLZDDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  24
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)
  申请人：Sirna Therapeutics, Inc.

  公开号：US20170029824A1

  公开（公告）日：2017-02-02

  The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of CTNNB1 gene expression and/or activity, and/or modulate a beta-catenin gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that medium RNA interference (RNAi) against CTNNB1 gene expression.