2-[4-(2-hydroxy-phenylamino)-piperidin-1-yl]-N-quinolin-6-yl-acetamide | 1023288-77-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[4-(2-hydroxy-phenylamino)-piperidin-1-yl]-N-quinolin-6-yl-acetamide
• 英文别名: 2-[4-(2-hydroxyanilino)piperidin-1-yl]-N-quinolin-6-ylacetamide
• CAS: 1023288-77-8
• 化学式: C₂₂H₂₄N₄O₂
• 分子量: 376.458
• InChiKey: NGSQEYFDGJYQTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  77.5
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Phenylamino-substituted piperidine compounds, their preparation and use as medicaments
  申请人：Laboratorios del Dr. Esteve S.A.

  公开号：EP1918281A1

  公开（公告）日：2008-05-07

  The present invention relates to phenylamino-substituted piperidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans or animals.

  本发明涉及一般式（I）的苯胺取代哌啶化合物，其制备方法，包含这些化合物的药物以及它们用于制备治疗人类或动物的药物的用途。
• PHENYLAMINO-SUBSTITUTED PIPERIDINE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS
  申请人：Garcia-López Mónica

  公开号：US20100099703A1

  公开（公告）日：2010-04-22

  The present invention relates to phenylamino-substituted piperidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans or animals.

  本发明涉及一般式（I）的苯氨基取代哌啶化合物，其制备方法，包含这些化合物的药物以及它们用于制备用于治疗人类或动物药物的药物的用途。
• [EN] PHENYLAMINO-SUBSTITUTED PIPERIDINE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS<br/>[FR] COMPOSÉS DE PIPÉRIDINE À SUBSTITUTION PHÉNYLAMINO, LEUR PRÉPARATION ET LEUR UTILISATION EN TANT QUE MÉDICAMENTS
  申请人：ESTEVE LABOR DR

  公开号：WO2008052769A1

  公开（公告）日：2008-05-08

  [EN] The present invention relates to phenylamino-substituted piperidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans or animals.
  [FR] La présente invention concerne des composés de pipéridine à substitution phénylamino de formule générale (I), leurs procédés de préparation, des médicaments comprenant ces composés, ainsi que leur utilisation pour la préparation d'un médicament pour le traitement d'humains ou d'animaux.