3-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-isoxazole-5-carboxylic acid (2-hydroxy-ethyl)-amide | 1240401-99-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-isoxazole-5-carboxylic acid (2-hydroxy-ethyl)-amide
• 英文别名: 3-[[3-(5-fluoropyridin-2-yl)-5-methyl-1,2-oxazol-4-yl]methoxy]-N-(2-hydroxyethyl)-1,2-oxazole-5-carboxamide
• CAS: 1240401-99-3
• 化学式: C₁₆H₁₅FN₄O₅
• 分子量: 362.317
• InChiKey: FHHOSCQLYHJNSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• ISOXAZOLE-ISOXAZOLE AND ISOXAZOLE-ISOTHIAZOLE DERIVATIVES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2398782B1

  公开（公告）日：2013-09-18
• US8173652B2
  申请人：——

  公开号：US8173652B2

  公开（公告）日：2012-05-08
• [EN] ISOXAZOLE-ISOXAZOLE AND ISOXAZOLE-ISOTHIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'ISOXAZOLE-ISOXAZOLE ET D'ISOXAZOLE-ISOTHIAZOLE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2010094669A1

  公开（公告）日：2010-08-26

  The present invention is concerned with isoxazole-isoxazole and isoxazole-isothiazole derivatives of Formula (I), having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.