Methyl 2-(2-amino-4-methylpentanamido)-3-phenylpropanoate hydrochloride | 37885-98-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 2-(2-amino-4-methylpentanamido)-3-phenylpropanoate hydrochloride
• 英文别名: methyl 2-[(2-amino-4-methylpentanoyl)amino]-3-phenylpropanoate;hydrochloride
• CAS: 37885-98-6
• 化学式: C16H25ClN2O3
• 分子量: 328.83
• InChiKey: ZFDDNDZIYSOTHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.68
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  81.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] PROCESS FOR THE PREPARATION OF (2S)-N-((S)-1-((S)-4-METHYL-1-((R)-2-METHYL OXIRAN-2-YL)-1-OXOPENTAN-2-YLCARBAMOYL)-2-PHENYLETHYL)-2-((S)-2-(2-MORPHOLINO ACETAMIDO)-4-PHENYLBUTANAMIDO)-4-METHYLPENTANAMIDE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE (2S)-N-((S)-1-((S)-4-MÉTHYL-1-((R)-2-MÉTHYL OXIRAN-2-YL)-1-OXOPENTAN-2-YLCARBAMOYL)-2-PHÉNYLÉTHYL)-2-((S)-2-(2-MORPHOLINO ACÉTAMIDO)-4-PHÉNYLBUTANAMIDO)-4-MÉTHYLPENTANAMIDE
  申请人：MSN LABORATORIES PRIVATE LTD

  公开号：WO2016170544A1

  公开（公告）日：2016-10-27

  The present invention relates to process for the preparation of (2S)-N-((S)-l -((S)-4-methyl-1 -((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylcarbamoyl)-2-phenylethyl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)-4 -methylpentanamide represented by the following structural formula-1.

  本发明涉及一种制备(2S)-N-((S)-l -((S)-4-甲基-1-((R)-2-甲氧基环氧丙基-1-氧代戊基氨基)-2-苯乙基)-2-((S)-2-(2-吗啉基乙酰氨基)-4-苯基丁酰氨基)-4-甲基戊酰胺的方法，其结构式如下所示-1。
• Process for the preparation of (2S)-N-((S)-1-((S)-4-methyl-1-((R)-2-methyl oxiran-2-yl)-1-oxopentan-2-ylcarbamoyl)-2-phenylethyl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)-4-methylpentanamide
  申请人：MSN LABORATORIES PRIVATE LIMITED

  公开号：US10544189B2

  公开（公告）日：2020-01-28

  The present invention relates to process for the preparation of (2S)-N-((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylcarbamoyl)-2-phenyethyl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)-4- methylpentanamide represented by the following structural formula-1.

  本发明涉及制备(2S)-N-((S)-1-((S)-4-甲基-1-((R)-2-甲基环氧乙烷-2-基)-1-氧代戊-2-基氨基甲酰基)-2-苯基乙基)-2-((S)-2-(2-吗啉乙酰氨基)-4-苯基丁酰氨基)-4-甲基戊酰胺的工艺，其结构式如下-1。
• PROCESS FOR THE PREPARATION OF (2S)-N-((S)-1-((S)-4-METHYL-1-((R)-2-METHYL OXIRAN-2-YL)-1-OXOPENTAN-2-YLCARBAMOYL)-2-PHENYLETHYL)-2-((S)-2-(2-MORPHOLINO ACETAMIDO)-4-PHENYLBUTANAMIDO)-4-METHYLPENTANAMIDE
  申请人：THIRUMALAI RAJAN Srinivasan

  公开号：US20180298056A1

  公开（公告）日：2018-10-18

  The present invention relates to process for the preparation of (2S)—N—((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylcarbamoyl)-2-phenyethyl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)-4- methylpentanamide represented by the following structural formula-1.